Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Abeta"”.
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Single-molecule studies of alpha-synuclein and abeta in Parkinson’s disease derived biofluids
… soluble aggregates of alpha-synuclein (αS) and Abeta (Aβ), often referred to as oligomers, are more neurotoxic than mature fibrils. Thus, this work aims to study the structural and biological properties of αS and Aβ aggregates involved in Parkinson’s disease. To understand the protein-specific …
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Molecular mechanism of Abeta recognition and neuroprotection by the glycoconjugate beta-sheet-breaker peptide Ac-LPFFD-Th
… To this regard, peptide-based inhibitors of Abeta aggregation have been widely investigated with a particular emphasis to those derived from original amyloid sequences. The experimental work described in the present PhD Thesis aims at outlining the molecular mechanisms underlying the …
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… molecular culprit in AD is the amyloid-beta (Abeta) peptide, aggregates of which are the main components of the plaques. Numerous studies have implicated soluble Abeta oligomers as the predominant neurotoxic species, although the underlying mechanisms that lead to cognitive failure are not …
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Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease
… to the crucial role of amyloid-beta protein (Abeta) in the pathogenesis of the disease; in fact, the feature in the brain of AD patients is the presence of extracellular plaques mainly composed of Abeta. Nevertheless, Abeta is physiologically produced in healthy individuals. Due to its …
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The Role of Metal Ions and Reactive Oxygen Species in beta-Amyloid Aggregation and Toxicity and Their Relevance to Alzheimer's Disease.
… study investigates the generation of H2O2 by Abeta during the process of aggregation and presents evidence supporting the hypothesis that some form of Ap oligomer has the capacity for H2O2 generation. A technique developed to immobilise Abeta during its aggregation suggested H2O2 generation to …
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Amyloid Fibril Nucleation In Reverse Micelles
The 40-residue amyloid beta protein (Abeta) is the unstructured cleavage product of a common membrane protein that is produced in large quantities, but normally cleared from the brain before it exerts any apparent toxicity. Under some conditions, however, it undergoes a conformational change and …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… macular degeneration (AMD) using amyloid-beta (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight (LMW) compounds capable of interacting with soluble Abeta may be able to modulate/inhibit the Abeta aggregation process and serve as potential …
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Structure and activity of human clusterin.
… components, Alzheimer's disease amyloid beta (Abeta) peptides, and apo AI-HDL in addition to immunoglobulins, TGFbeta receptors, heparin and the endocytic receptor LRP2. Little is known of clusterin structure and function. Sequences modeled as amphipathic alpha helices have been proposed as …
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Identification of HIV protease mutants with improved specificities toward an Alzheimer's Disease associated peptide sequence
… octapeptide taken from the beta-amyloid peptide (Abeta) implicated in Alzheimer's Disease. Quantitative Western blotting of E. coli extracts revealed approximately 20- and 30-fold increases in proteolytic specificity and activity, respectively, toward the Abeta octapeptide relative to a native …
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Localised Dosing and Nanodetection Using a Novel Scanning Ion Conductance Microscope and Its Application to Alzheimer's Disease
… of the effectiveness of antibodies that bind to Abeta or alpha-synuclein (Asyn)peptides depends on the measurement of oligomer-induced abnormal calcium homeostasis in single astrocytes. The method was shown to work at physiological concentrations of oligomers. A series of experiments measuring …
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Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer
… principales son las placas seniles (placas de Abeta) y los ovillos neurofibrilares (agregaciones intracelulares de Tau). Además, se registra pérdida neuronal y un proceso neuroinflamatorio mediado por las células gliales (astrocitos y microglía). Los continuos fracasos terapéuticos, …
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Reconstituting APP and BACE in proteoliposomes to characterize lipid requirements for β-secretase activity
… protein (APP) may lead to the formation of the Abeta peptide, the major constituent of amyloid plaques in Alzheimer`s disease. The full-length APP is a substrate for at least 2 different (alpha and beta) proteases ("secretases"). The beta-secretase, BACE, cleaves APP in the first step …
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Protein Misfolding and Aggregation in Neurodegeneration: In Vitro And In Vivo Study Cases
… of AD have been identified. Accumulation of Abeta and fibrillary tangles as well as impairments in working and learning memory are age-related hallmark of AD pathology. To produce a progressive characterization of Abeta and tau pathology in 3xTg-AD mice we aged female mice at 2, 6, 12 and 20 …
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Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
… angiopathy (CAA) refers to the deposition of Abeta (Aβ) peptides in the brains small blood vessels leading to hemorrhagic stroke and cognitive impairment. Aβ is toxic to smooth muscle cells and impairs blood flow regulation. Reduced blood oxygen level dependent (BOLD) signal amplitude in …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… from misfolded proteins such as amyloid beta (Abeta), tau, and alpha-synuclein (aSyn). Although these protein deposits correlate to some extend with disease progression and cognitive decline, increasing evidence suggests that small intermediate aggregate species called oligomers are the primary …
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
… to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate and form clumps that deposit outside neurons, and are believed to trigger the disease. In this dissertation, I use …
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Kinetic and structural evolution of functional peptide assembling networks
… investigated with the pH sensitive Abeta(16-22) peptide, which assembles into fiber at neutral pH but tubes at acidic pH. The difference between the nucleation and propagation environments for the two-step nucleation mechanism affects the assembly kinetics and morphological …
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