Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Aberrant Wnt"”.
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
The Wnt/Beta-catenin signaling pathway has many roles including regulation of developmental pathways, cell proliferation, and homeostasis of adult tissues. Wnt/Beta-catenin signaling activity depends on the stability and localization of Beta-catenin in the cell. In the absence of a Wnt-signal, …
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
… to this subpopulation of tumour cells. Wnt activity and β-catenin signalling have been associated with different types of cancer and microarray data from our laboratory highlighted upregulation of members of the Wnt pathway in primary prostate cancer stem cells. Therefore, the aim of …
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Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
… signaling pathways, Hedgehog (HH) and Wnt signaling pathways. HH signaling is vital for metazoan development, and its ligand is secreted by a cell surface protein named Dispatched-1 (DISP1). I report the cryo-EM structure of the DISP1 in complex with dual lipid-modified HH ligand, …
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The Role of SOX2 in Colon Cancer Progression
… poor prognosis and decreased patient survival. Aberrant Wnt signaling drives the colo-rectal carcinogenic process and is a major determinant of the disease outcome. This study demonstrates that SOX2 counteracts Wnt driven tumor cell proliferation and maintains quiescence in a sub-population of …
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A decrease in dkk1, a Wnt inhibitor, contributes to placental and fetal lipid accumulation in an obesity-prone rat model
Made available in DSpace on 2011-05-25T15:06:43Z (GMT). No. of bitstreams: 6 Appendix B-qRT-PCR Curves.pdf: 4421573 bytes, checksum: e9ba82137f083fa9f50680e7baf8c92c (MD5) Appendix A-Rodent Obesity Models.pdf: 102817 bytes, checksum: d22fc8b17473156234c55d696e75cadd (MD5) Strakovsky_Rita.pdf: …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… AIM2 were prone to uncontrolled proliferation. Aberrant Wnt signaling expanded a population of tumor-initiating stem cells in the absence of AIM2 driving the tumor development in AIM2-deficient mice. In addition to its role in cancer, AIM2 recognizes bacteria including <em>Francisella tularensis …