Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Abasic site"”.
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A study of the formation of interstrand and intrastrand crosslinks through abasic site and cleaved abasic site chemistry
… damage is the formation of apurinic/apyrimidinic sites (known as abasic sites); which occur at least 10,000 times per cell per day. If left unrepaired, subsequent damages such as interstrand crosslinks or strand cleavage can arise. While numerous studies have been conducted on crosslinks and …
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Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability
… dependent. Guanines are the primary damage sites, but damage of adenine and thymine is also possible. Based on our studies, telomeric DNA can be readily oxidized to produce DNA lesions. How do DNA lesions affect the conformation and the stability of telomeric G-Quadruplex DNA? In the second …
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High-resolution mapping of abasic sites and pyrimidine modifications in DNA
… leading to the formation of damage products. Abasic sites occur when a nucleobase is lost from DNA by hydrolysis and can lead to mutations and genomic instability. This thesis focuses on the development and application of methodology to map the location of abasic sites in DNA by …
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Single-Molecule Studies Of Local And Global Nucleic-Acid Dynamics
… Local dynamics using 2AP across a DNA abasic-site mimic, SAM-1 riboswitch binding pocket reorganization, and tRNAPro 3' end are reported. </p> <p>Additionally, RNA global motions in conditions with molecular crowding, which mimics the cellular environment, are reported using the …
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INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION
… Taken together, our model suggests that the abasic site originating from cytosine methylation turnover partially results in the vulnerability of the nascent strand for nuclease-mediated degradation. Targeting the histone methylation pathways, particularly H3K9Me3 revealed a strong …
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The iron-dependent cyanide and hydrogen peroxide co-toxicity in Escherichia coli and its catastrophic consequences for the chromosome
… removed by base-excision repair via the abasic site intermediates. These lesions can be converted into double-strand breaks that are repairable via the recombinational repair system. On the other hand, termination of the CN + H2O2 treatment, which results in termination of the CN-induced …
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RAD51-MEDIATED ABASIC SITES PROTECTION PREVENTS REPLICATION FORK COLLAPSE.
… produces as a result DNA lesions, among which abasic (AP) sites are the most prevalent in genomic DNA, occurring at an estimated rate of 10,000 to 20,000 per cell per day. Under normal conditions, AP sites on double-stranded DNA are primarily repaired by the base-excision repair (BER) pathway. …