Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"AZD6244"”.
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Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma
… found PDAC lines to be particularly sensitive to AZD6244, while normal cell lines are significantly less sensitive. The combination or either an mTOR or Raptor hairpin and AZD6244 was found to be additive in that the effect on viability is significantly greater than that of each intervention …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… combination of MLN3651 and the MEK1/2 inhibitor AZD6244 had additive effects, particularly in meningioma. Combinatorial therapy activated the Hippo pathway, inhibited RAF/MEK/ERK pathway activity and proliferation demonstrating that targeting the activity and downstream pathways of both DCAF1 and …