Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"AXL"”.
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The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous epithelium. A sequence homology search identified an uncharacterized …
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Deciphering AXL-Driven Molecular Mechanisms of EMT
Pages xviii-xix are misnumbered as pages xix-xx.
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Axl RTK and microRNAs in urogenital cancers
… thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
<p>AXL, a receptor tyrosine kinase, is known to promote malignant phenotypes in various types of cancer. AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of …
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The Soluble Form of the Axl Receptor Tyrosine Kinase
The present investigation focus on the receptor Axl, which is a member of the receptor tyrosine kinase family. Axl is activated by the ligand Gas6 inducing cell growth and proliferation, but also regulate inflammation and vascular homeostasis. The Axl receptor can be cleaved outside the membrane, …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… associated with persistent immune suppression. AXL, a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family, has been identified as a critical factor that drives metastasis and immune suppression in many cancer types. Here we demonstrate that AXL-deficient PDA bearing mice have …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… of EMT. Accordingly, the EMT-related kinase AXL was highly associated with the presence of CD163+ TAM. Tumours from relapsing patients presented a high expression of AXL and CD163, although only AXL retained independent prognostic significance in multivariate analysis. In vitro analysis …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… effective drug-based treatments.<br/>TAM (TYRO3, AXL and MERTK) family receptors are involved in tumour development, progression, metastasis and resistance to targeted therapies in several cancers. Our group previously showed overexpression and hyper-activation of all three TAM family receptors …
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A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
… study of the receptor tyrosine kinase Axl, whose overexpression and activation is implicated in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 …
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The Role of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma and Its Regulation By Hematopoietic Progenitor Kinase 1
… with PDA. Oncogenic receptor tyrosine kinase Axl has been reported to be overexpressed in many types of human malignancies, including diffuse glioma, melanoma, osteosarcoma, and carcinomas of lung, colon, prostate, breast, ovary, esophagus, stomach, and kidney. However, the expression and …
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Development of novel receptor tyrosine kinase inhibitors by a chemocentric approach
… fewer programs being run in the manner. The AXL kinase is a receptor tyrosine kinase (RTK) and a member of the TAM family, along with MER and TYRO3. AXL has long been associated with numerous types of cancer. Having been first discovered in 1991 in acute myeloid leukaemia (AML), it has gone …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… cancers.</p> <p>In this thesis, we identified AXL as a potential therapeutic target in IBC due to its role in generating an immunosuppressive TME. Indeed, inhibiting the AXL pathway suppresses IBC tumor growth and reduces M2 macrophage populations in various mouse models. Mechanistically, AXL …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… NSCLCs. We found that systemic inhibition of Axl results in increased type I interferon secretion from dendritic cells that expands tumor-associated TCF1+ PD-1+ CD8 T cells, restoring therapeutic response to PD-1 ICB for KPL tumors. This effect was observed in syngeneic immunocompetent mouse …
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Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer
… Upon integrated analysis, we find both Axl and Her2 have increased lysate levels after Mek inhibition with 3 Mek inhibitors, Selumetinib, Binimetinib, and PD0325901. Axl changes are attributed to a decrease in proteolytic shedding and protein degradation, and Her2 changes are attributed …
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The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… and HES5, while shRNA’s was used to knock down AXL and catulin in mutant cell lines to evaluate tumor growth.</p> <p><strong>Results:</strong> We show here that restoration of full length NOTCH1 in mutant HNSCC cell lines and activation of NOTCH signaling in wild-type cell lines significantly …
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Probing the Molecular Requirements for Breast Cancer Cell Motility
… factor Slug and the tyrosine kinase Axl. Additional functional analyses revealed that Slug, Axl and miR205 contributed to migration through their actions within parallel signaling pathways. Furthermore, using, an orthotropic xenograft model, we determined that deltaNp63alpha and Slug …
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Régulation de l'activité transcriptionnelle de Sox9 et Axl par des facteurs de transcription de la classe bZIP chez les cellules de Sertoli des testicules
… la transcription de leurs gènes cibles tels que Axl et Sox9. "--Sommaire.
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Molecular Players in Lupus: Leads from Proteomic Screens
… pathogenesis. We have discovered that soluble Axl receptor tyrosine kinase, the Wnt/β-catenin pathway-related factors, and rare fibrinogen alpha chain variant A-α-E are elevated in the serum of patients with SLE. Here I explore these factors and their contributions to disease. I find that Axl …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… their secretion of GAS6 which</p> <p>activates AXL in cancer cells, consistent with heterotypic symbiotic</p> <p>signaling in the TME. Thus, APC-deficiency activates a TCF4-TDO2-AhR-</p> <p>CXCL5-GAS6-AXL circuit that impacts multiple cancer hallmarks via</p> <p>autonomous and non-autonomous …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
… secreted pro-metastatic proteins, IL8, AXL and uPAR; (2) the reduction in glycocalyx levels caused by both the entire secretome and IL8, AXL and uPAR individually, was reflected by an increase in the adhesion of TNBCs to a cerebral EC monolayer under flow conditions. This interaction may …
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