Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"AURKA"”.
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Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
… its highest co-expression with Aurora kinase A (AURKA) pathway members, i.e. with AURKA and its binding co-factor and activator TPX2, all being localized on chromosome 20q. In addition, preliminary immunoblotting experiments in a panel of ten CRC cell lines showed high positive correlation …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
… using the oncogenic kinase Aurora kinase A (AURKA) as a model substrate. Many small molecule inhibitors of AURKA have failed during clinical development due to dose-limiting toxicities and the emergence of resistance mechanisms. MLN8237 (alisertib) is an example of a high-affinity, selective …
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
Aurora kinase A (AURKA) is a major mitotic regulatory kinase required for mitotic entry, the formation of a bipolar mitotic spindle, and the completion of cytokinesis. In recent years AURKA has been identified as an upstream regulator for many interphase functions such as cilia disassembly and …
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A novel route to oncogenic activation of cell cycle kinase Aurora A
Aurora kinase A (AURKA) is a major positive regulator of the cell cycle, required for the onset of mitosis and the completion of cell division. Recent research has uncovered roles of AURKA that are independent of the kinase activity and that regulate multiple cellular processes, including motility, …
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A study of novel tools to measure and perturb Aurora Kinase A protein stability
… study the relative stability of Aurora Kinase A (AurKA). AurKA is a serine/threonine protein kinase that has well documented functions in the onset and progression of mitosis by promoting centrosome maturation and mitotic spindle assembly. The cognate pathway of AurKA degradation is through the …
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SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs
… screening, we show here that Aurora kinase A (AURKA) activity is essential in NSCLCs carrying SMARCA4/BRG1-inactivating mutations. RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and diminish cellular viability in SMARCA4/BRG1-mutant NSCLC cells in vitro and in mouse …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… methyltransferases (DNMTs), and aurora kinase A (AurkA) can promote neuroblast differentiation and decrease proliferation. The combination of the DNMT inhibitor decitabine with the AurkA inhibitor MLN8237 enhances differentiation and reduces proliferation compared to either agent alone. …
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Modulation of the aquaporin-2 localization in renal principal cells
… of a hitherto unknown role of aurora kinase A (AURKA) in the control of the AQP2 localization. Two AURKA-selective inhibitors, aurora-A inhibitor I and alisertib, inhibited the cAMP-dependent AQP2 redistribution in two cell models by effects on the actin cytoskeleton. Novel derivatives of …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… inhibiting other kinases, namely aurora A (AURKA), p38 (MAPK14) and Hgk(MAP4K4). These compounds represent exciting potential new anti-cancer compounds dueto the fact that they inhibit cancer-associated kinases whilst displaying low cytotoxicity.
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SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.
… progression and spindle stabilization such as AURKA and NEDD1, in amphiregulin-supplemented IVM. Furthermore, this assay allowed to assess that the poly(A) tail in immature oocytes was 100 bp-long, providing an explanation for the inability of observing differences when using random hexamers …