Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AU-rich elements"”.
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… RNA binding proteins, selectively binds to AREs (AU-rich elements) and mainly stabilizes ARE-containing mRNAs, e.g. TNFα, VEGF, c-FOS, favoring specific protein translation. TNFα mRNA is one of the most important target mRNA of HuR since the protein encoded by this gene mediates the inflammatory …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… ZFP36L1, which binds to adenylate/uridylate (AU)-rich elements (AREs) (AU-RBP) in the 3’ untranslated region of many messenger RNAs, has been extensively characterised for its role in post-transcriptional control of gene expression and is reported as a newly identified cancer driver gene. …
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Principles of HuR-RNA targeting, interaction dynamics, and functional outcomes
… of target mRNAs through binding to ARE (AU-rich elements) in the 3' UTR (untranslated region) of protein coding transcripts. In response to certain stimuli, HuR is subject to post-translational modifications and changes subcellular localization, which impacts its regulatory capacity. In …
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Apobec-1 Complementation Factor (ACF) Binds and Regulates Multiple RNAs
AU-Rich Elements: ARE) are cis-acting RNA sequences in the 3'UTRs of a wide range of transcripts that function to regulate mRNA stability, localization, and/or translation through interaction with ARE-Binding Proteins. Apobec-1 Complementation Factor: ACF) was originally identified as a co-factor …
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Regulation and function of the RNA-binding protein CELF1
… Etr3 Like Factor 1 (CELF1). CELF1 binds to a GU-rich element (GRE) harbored in target transcripts and promotes their rapid decay through the recruitment of RNA decay enzymes. The work presented in this thesis focused on elucidating the function and regulation of CELF1 mediated mRNA decay through …
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The Regulation of ARE-Mediated mRNA Decay During Colorectal Tumorigenesis
… cancer among American adults and a leading cause of cancer-related mortality. The initiation and progression of colorectal tumorigenesis is characterized by genetic alterations that account for uncontrolled expression of many growth- and inflammation-associated genes. In the normal, …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
… of CCCH tandem zinc finger proteins bind to AU-rich elements in the 3' untranslated regions of certain cellular mRNAs, leading to their deadenylation and destabilization. Studies in knockout mice have demonstrated roles for three of the family members, TTP, ZFP36L1 (L1), and ZFP36L2 (L2), in …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
Pancreatic cancer is the 4th leading cause of cancer-related death in the U.S. in 2019. The five-year survival rate for all stages combined is only 9%, which is the lowest among all types of cancer. The current chemotherapeutic regimens for pancreatic cancer, including gemcitabine, FOLFIRNOX, and …