Global ETD Search
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Showing 1 to 7 of 7 for “"AU-rich element"”.
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
… domain and the RNA helicase associated with AU-rich element (RHAU) specific motif (RSM), which allows RHAU binding to G4 RNAs and subsequent unwinding of G4 RNA into single-stranded transcripts. We hypothesize that RHAU functions in CSR by binding G4 S transcripts and resolving them into …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… rapid transcript decay in mammalian cells is the AU-rich element (ARE), which is found in the 3’ untranslated region (UTR) of many labile transcripts. These sequence elements confer destabilization of transcripts by binding to AU-binding proteins (AUBPs) that can recruit cellular decay enzymes. …
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Analyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
… Gal1. Our results indicate that the absence of AU-rich element (ARE) sequence in Gal1 3’UTR may be one of the factor leading to Gal1 mRNP formation at the transcription site. Moreover, our data shows that by introducing the ARE sequence (TATTTAT), between the two cleavage sites of Gal1 3’UTR, it …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… are targeted for rapid degradation through AU-rich element (ARE) motifs present in the mRNA 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an RNA-binding protein that plays a significant role in regulating the expression of ARE-containing mRNAs. Through its ability to bind AREs and …
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Role of the Hu family of RNA-binding proteins in regulating acetylcholinesterase expression in excitatory cells
… and transiently. We examined the role of the AU-rich element (ARE) found in the 3'-UTR and of the RNA-binding protein (RBP) HuD in modulating AChE mRNA levels. Using a combination of complementary binding assays and transfection assays we demonstrated direct binding of HuD to the ARE and the …
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Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells
… of the GA mRNA that is mediated by two 8-base AU-sequences that function as pH-response elements (pHRE). This sequence binds ζ-cryst and p40-AUF1 with high affinity and specificity. An in vitro mRNA decay assay was developed using cytosolic extracts of WKPT cells, a line of rat renal proximal …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
<p>Lung cancer is the leading cause of cancer-related deaths in the United States, largely due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are …