Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"ATRA"”.
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The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
All trans retinoic acid (atRA) has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells. This results from arrest of the cell cycle during the G1 phase. G1 checkpoint is regulated by a multitude of molecules, including the retinoblastoma family of proteins, cyclin dependent kinases …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… drug release and anticancer efficacy. The ATRA loaded PONC showed excellent encapsulation efficiency and release kinetics. Even after surface functionalization with PEG , controlled drug release kinetics was maintained, with 88.5% of the encapsulated ATRA released from the PEG-PONC in a …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
All-trans retinoic acid (ATRA) is successful in treating acute promyelocytic leukemia but has shown limited success with other cancers. Identifying signaling pathways that confer ATRA responsiveness and compounds that enhance the effects of the drug could expand its therapeutic efficacy. The …
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… by Th2 helper cells. All-trans retinoic acid (ATRA) is a product of metabolism of dietary retinol (vitamin A). In a manner analogous to hormones, ATRA binds to nuclear receptors in cells and influences gene expression and cell physiology. ATRA is important in the resolution of inflammation …
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Interaction between retinoids and methyl group metabolism
… relationship between all-trans-retinoic acid (ATRA) administration and induction of GNMT, as well as determining additional indices of methyl group and folate metabolism. For the dose-response study, rats were given either 0, 1, 5, 10, 15 or 30 [mu]mol ATRA/kg BW for 10 d. For the time-course …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… c-Myc expression during all-trans-retinoic acid (ATRA)-induced differentiation that accelerated differentiation and reduced proliferation of acute promyelocytic leukemia HL-60 cells. TIS21 downregulated c-Myc mRNA and additionally decreased c-Myc protein stability by increasing its phosphorylation …
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Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… of this is the use of all-trans-retinoic acid (ATRA) in the treatment of acute promyelocytic leukaemia (APL). The differentiation of APL cells treated with ATRA in vitro is a model that allows the examination of differentiation pathways in myeloid leukaemic cells. Using this principle, my thesis …
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The Biological Effects of Novel Synthetic Retinoids
… showed that EC23 is far more toxic than EC19 or ATRA, while being far more able to create retinoid limb phenotypes at lower concentrations. EC19 in this investigation is shown to produce very few retinoid limb phenotypes in comparison, but is able to yield a far higher frequency of retinoid …
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Beneath the Beauty: A Mixed Method Approach to Examining Identity Negotiation Among Asian Transracial Adoptees
… families, making Asian transracial adoptees (ATRAs) a substantial, if frequently overlooked, proportion of the Asian American community. Prior research indicates that identity negotiation is a particularly daunting task for this demographic due to ever-present paradoxical feelings toward their …
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Synthetic Degradable Polymer Systems for Drug Delivery
… and release of all-trans retinoic acid (ATRA), a promising anti-cancer therapeutic. The effect of the cross-linking approach and ATRA loading on the physical properties of the hydrogels were evaluated, and the ATRA release profile as well as hydrogel cytotoxicity were evaluated in vitro. …
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Synthesis and Characterization of Ruthenium (II) Complexes and their Applications to Atom Transfer Radical Addition Reactions
… for the atom transfer radical addition (ATRA) of various chloro-substrates (CCl4, CHCl3, p-TsCl, CCl3CO2Et, and CH2ClCO2Et) to styrene in the presence of AIBN as a radical source. For comparison purposes, we also investi<ated the activity of Cp#Ru(PPh3)2Cl and Cp#Ru(PTA)2Cl complexes …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
… and are more potent than their natural analogues ATRA and 13cisRA. The high potency of synthetic retinoids such as EC23 implies that they do not undergo metabolism. An in vivo investigation into the metabolism of retinoids was initiated. AG1 X2 polymer beads were used to deliver various …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… cancer cells with all-trans retinoic acid (atRA) also resulted in increased expression of ALDH1A3 and ALDH3A1, supporting a feedback loop between atRA and ALDHs. Furthermore, SerBob, Bob and LNCaP cells were sensitive to treatment with epigenetic drugs and led to significantly higher …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… cancer cells with all-trans retinoic acid (atRA) also resulted in increased expression of ALDH1A3 and ALDH3A1, supporting a feedback loop between atRA and ALDHs. Furthermore, SerBob, Bob and LNCaP cells were sensitive to treatment with epigenetic drugs and led to significantly higher …
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Λειτουργική και γονιδιωματική ανάλυση της επίδρασης αναλόγων του ρετινοϊκού οξέος σε ανθρώπινα κερατινοκύτταρα
… γίνεται χρήση του all-trans ρετινοϊκού οξέος (atRA) σε διάφορα αντι-καρκινικά θεραπευτικά σχήματα. Η πιθανή θεραπευτική αποτελεσματικότητα των ρετινοειδών στον καρκίνο ενισχύεται από στοιχεία που δείχνουν, ότι τα ρετινοειδή αναστέλλουν την αγγειογένεση η οποία είναι σημαντική για την ανάπτυξη …
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Analisis kandungan timbal (Pb) pada talus lichenes di Kabupaten Lamongan
… sp, Graphis sp, Hafellia levieri, Opegrapha atra, Lecidella elaeochroma, Cryptothecia scripta, dan Parmelia sulcata. Terdapat perbedaan kadar Timbal (Pb) pada Talus Lichenes di lima stasiun pengamatan di kabupaten Lamongan, yang di pengaruhi oleh kepadatan lalu lintas. Kadar Timbal (Pb) …
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Plasma membrane-derived vesicles: composition and function
… with exosomes.Agents (Histamine, PMA, ATRA) currently used in differentiation therapy for the treatment of acute myelocytic leukaemia (AML), are reported here to induce the release of PMVs from various cells and to halt the overproliferation of THP-1 promonocytes in vitro. Further …
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Aplicación de técnicas de control y procesamiento de señales en amplificadores de audio de alta eficiencia y baja distorsión
… distorsión generada en las diferentes etapas que atra-viesa la señal. El desarrollo es teórico-práctico. Varios esque-mas de modulación por ancho de pulso son estudiados en el dominio frecuencial. Se analiza además el efecto de los tiempos muertos necesarios entre el encendido y el apagado de los …
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Morphological, ecological and molecular examination of the seacucumber species along the Red Sea coast of Egypt and Gulf of Aqaba : with the investigation of the possibility of using DNA barcoding technique as a standard method for seacucumber ID
… complex were also identified for the Holothuria atra population in the Red Sea using the molecular analysis of the mitochondrial COI gene.In this study another experiment were conducted in order to identify sea cucumber species from cooked or dried materials using the molecular techniques. As …
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Plasma membrane-derived vesicles: their role in the terminal differentiation of monocytes and in inhibiting the phagocytosis of apoptotic cells
… promonocytes. The myeloid differentiating agents ATRA, PMA and histamine, which inhibit promonocyte proliferation, induced an intracellular Ca2 +-mediated PMV (as opposed to exosome) release from HL-60 promonocytes. These PMVs caused HL-60 cells to enter GO/G 1 cell cycle arrest and induce …
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