Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ATR signaling"”.
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ATR SIGNALING IN GENOME REPLICATION AND MAINTENANCE
… by these challenges activates the sensor kinase ATR in mammals (Mec1 in S. cerevisiae), which coordinates a multifaceted cellular response that is essential for maintaining genome integrity. Over the last few decades, ATR’s role in controlling the checkpoint upon the DNA damage response has been …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… to sites of replication stress to maintain ATR signaling.</p> <p>The stability of p53 is largely dependent on its negative regulator, the MDM2 ubiquitin E3 ligase. Here, we provide evidence that in addition to its role as an upstream regulator of DNA damage response, BRIT1 is able to …
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
… with telomere replication stress, including ATR signaling, fork stalling, sister telomere associations, and fragile telomeres. Fragile telomeres are structures that resemble common fragile sites (CFSs), but how they are formed is not known. TRF1 functions in part by recruiting the BLM …
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Identification and Characterization of the DNA Damage Response Function of Human Rif1 and a Search For Human Rap1 Interacting Factors
… on the ATM kinase. Whereas inhibition of ATR signaling did not suppress the Rifl response, ATM deficient cells treated with IR or UV lacked Rifl foci even after prolonged incubation or high radiation dose. Therefore, IR-induced Rifl foci constitute an assay for ATM status. The Rifl …
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Replicative Senescence is ATM-Driven, Reversible, and Delayed by Reduced ATM Activity at Low Oxygen
… telomeres lack su]icient TRF2 to repress ATM signaling. However, ATM-deficient cells also undergo replicative senescence, raising the question of POT1 deficiency and subsequent ATR signaling. Moreover, low oxygen culture conditions impart an extension of fibroblast proliferative lifespan, …
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Distinct DNA Damage Signaling in the Brain Distinguishes ATLD, NBS, and ATR-Seckel Syndrome
… to better understand the roles of ATM and MRN signaling in maintaining physical and functional integrity of the CNS, mutant mice either null for Atm or carrying hypomorphic mutations in Mre11 or Nbs1 were subjected to either endogenous or exogenous forms of DNA damage and the signaling response …