Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ATR inhibitor"”.
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A Neural Network and Genome Language Model Based Approach to Understanding DNA Replication in Cancer
… ecDNA. Chapter 3: DNA replication dynamics under ATR inhibitor treatment in a panel of six breast cancer cell lines Multiple clinical trials are underway to assess the performance of novel chemotherapeutics targeting the DNA replication stress response pathway. A central regulator of the …
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The role of innate immunity in pancreatic cancer progression and treatment
… with an Ataxia Telangiectasia and Rad3-related (ATR) inhibitor (Gem/ATRi) in pancreatic cancer, whereas the second project describes the pro-tumourigenic role of type 2 innate lymphoid cells (ILC2s) in PDAC. In chapter 3, Gem/ATRi showed preclinical efficacy in the ‘T cell high’ 2838c3 tumour …
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Role of Chk1 and Chk2 in mitotic checkpoint control in vertebrate cells
… replication arrest in the presence of the ATM/ATR inhibitor caffeine, further emphasizing the possibility of mitotic delay mechanisms that operate independently of ATM/ATR and Chk1. Furthermore, this study revealed that endogenous Cdc6 accumulates in a Chk1-dependent manner during replication …
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Targeting the DNA damage response protein ATR kinase in pancreatic cancer
… factor, Ataxia Telangiectasia and Rad3-related (ATR) kinase. Furthermore, many chemotherapies used in the treatment of PDAC increase RS, leading to ATR activation which limits the efficacy of these therapies. Therefore, there is good rationale for targeting ATR as a strategy for treatment of …
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The Tumor Suppressor PKCδ Is Critical for UV-Induced G2/M Checkpoint Activation and Apoptosis
… in the G2/M checkpoint. Treatment with the ATM/ATR inhibitor caffeine was unable to prevent PKCδ-cat induced G2/M arrest, suggesting that PKCδ-cat is functioning downstream of ATM/ATR in the G2/M checkpoint. To better understand the role of PKCδ and PKCδ-cat in the cell cycle response to DNA …
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The DNA damage response to ATR inhibition
The protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many …