Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ATR/ATM"”.
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Targeting survival pathways in cancer stem cells
… with tumor initiation, metastatization and treatment failure. CSCs are protected against standard medical treatments by multiple mechanisms including the abnormal activation of both DNA damage repair signals and canonical survival pathways. Moreover, this cellular subset relies on dedicated …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… in response to ionizing radiation (IR) treatments. Results indicated that Trp53 knockout did not affect radiation-induced circadian phase shifts, whereas increased p53 levels induced by transient inhibitor treatments prevented phase shifts when IR was performed at the trough of PER2 …
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ATR SIGNALING IN GENOME REPLICATION AND MAINTENANCE
… by these challenges activates the sensor kinase ATR in mammals (Mec1 in S. cerevisiae), which coordinates a multifaceted cellular response that is essential for maintaining genome integrity. Over the last few decades, ATR’s role in controlling the checkpoint upon the DNA damage response has been …
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The DNA damage response to ATR inhibition
The protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many …