Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 298 for “"ATR"”.
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ATR Process Geomatics: Process, Content, and Style
… dissertation examines the Addition to Reserve (ATR) for new reserve land parcel recovery within the Indian Act and other land management regimes applying to First Nations in Canada. The three portfolio papers explore a land-based geomatics data perspective, exploring its process, data practice, …
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ATR SIGNALING IN GENOME REPLICATION AND MAINTENANCE
… by these challenges activates the sensor kinase ATR in mammals (Mec1 in S. cerevisiae), which coordinates a multifaceted cellular response that is essential for maintaining genome integrity. Over the last few decades, ATR’s role in controlling the checkpoint upon the DNA damage response has been …
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The DNA damage response to ATR inhibition
The protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many …
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Targeting the DNA damage response protein ATR kinase in pancreatic cancer
… factor, Ataxia Telangiectasia and Rad3-related (ATR) kinase. Furthermore, many chemotherapies used in the treatment of PDAC increase RS, leading to ATR activation which limits the efficacy of these therapies. Therefore, there is good rationale for targeting ATR as a strategy for treatment of …
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
Hydrophilic matrices are widely used in the pharmaceutical industry as control release agents in solid oral dosage formulations. One of the key parameters that controls release in such systems is the distribution of exipients within the formulation, which in turn is governed by the processing and …
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Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis
… arise to maintain genomic integrity. ATM, ATR, and DNA-PKcs (encoded by PRKDC) are related phosphatidylinositol-3-kinase like serine/threonine kinases (PIKK) that collectively regulate the DDR network. Studies have demonstrated these kinases can phosphorylate many of the same substrates, …
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Advanced signal processing solutions for ATR and spectrum sharing in distributed radar systems
… solutions for AutomaticTarget Recognition (ATR) operations and for spectrum sharing in distributed radar systems.Two Synthetic Aperture Radar (SAR) ATR algorithms are described forfull- and single-polarimetric images, and tested on the GOTCHA and theMSTAR datasets. The first one exploits the …
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ATR-FTIR Measurements of Cationic Surfactant Exchange Rates at the Solid-Liquid Interface
In many experiments, surfactant adsorption and desorption at solid-liquid interfaces is found to be quite slow, considering that surfactants are small molecules. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the adsorption, desorption, and exchange of …
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Distinct DNA Damage Signaling in the Brain Distinguishes ATLD, NBS, and ATR-Seckel Syndrome
… Ataxia-telangiectasia and Rad3-related (ATR) is a large serine/threonine kinase that is highly similar in structure to ATM and phosphorylates many overlapping substrates. Hypomorphic mutations in ATR have been associated with some cases of Seckel syndrome, a microcephalic condition. …
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Investigation of membrane permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
Attenuated total reflectance Fourier transform (ATR-FTIR) spectroscopy and ATR-FTIR spectroscopic imaging was used for the in vitro monitoring of the mechanisms of drug permeation and the effects of penetration enhancers on silicone membrane and human stratum corneum (SC). Simulated spectroscopic …
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ATR-FTIR spectroscopy and Raman microscopy studies of organosilane diffusion and hydrolysis in PVC films.
… Fourier transform infrared spectroscopy (ATR-FTIR) and Raman confocal microscopy have been used to study the diffusion, hydrolysis and condensation of three organosilanes in silicon / PVC / silane laminates. These processes are thought to contribute to the formation of the IPN, and hence …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… to sites of replication stress to maintain ATR signaling.</p> <p>The stability of p53 is largely dependent on its negative regulator, the MDM2 ubiquitin E3 ligase. Here, we provide evidence that in addition to its role as an upstream regulator of DNA damage response, BRIT1 is able to …
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FTIR-ATR Characterization of Hydrogel, Polymer Films, Protein Immobilization and Benzotriazole Adsorption on Copper Surface
… (2EAE) to produce polymer films deposited on Si ATR crystal. Their moisture uptake property was tested using FTIR-ATR technique. This was evident by the decrease in -OH band in increasing N2 purging time of the films. Secondly, two monomer compounds namely vinyl acetic acid and glycidyl …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… utilize a common DNA repair signaling pathway — ATR/Chk1/STAT3 — to upregulate both CD47 and PD-L1 in response to radiotherapy, which through engagement of SIRPα and PD-1 suppresses the capacity of antigen-presenting cells to phagocytose them thereby preventing TAA cross-presentation and innate …
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Application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to measure sub-lethal effects of potential mutagens
… total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, was able to detect changes in various tissue samples exposed to varying levels of polycyclic aromatic hydrocarbons (PAHs). This technique discriminated between spatial and temporal variations in the interrogated tissues. …
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Non-destructive analysis of popular cigarette brands utilizing attenuated total reflectance (ATR) and diffuse reflectance infrared fourier transform spectroscopy (DRIFTS) and chemometrics
… to its ability of analyzing different sample matrices with a variety of techniques, infrared spectroscopy is highly effective at identifying the chemical composition of unknown samples. Popular techniques include Diffuse Reflectance Infrared Fourier Transform Infrared Spectroscopy (DRIFTS) and …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
Atrazine (ATR) is a selective pre- and post-emergence herbicide widely used for agricultural purposes as well as weed control in non-crop areas. Although banned from the European Union in 2006 due to potential environmental and health risks, this common environmental toxicant is heavily used in the …
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