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Showing 1 to 20 of 555 for “"ATPase"”.
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Proton-atpase in fish gills
… proton excretion rate and determining the proton ATPase activity in gill tissue under different inhibitor treatments and environmental conditions. Evidence for the existence of anelectrogenic proton pump in fish gills was accumulated. Branchial proton excretion rate was estimated by measuring the …
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Die Plasmamembran-Kalzium-ATPase im Myokard
Die Plasmamembran Kalzium-ATPase (PMCA) ist ein in den meisten eukaryontischen Zellen exprimiertes Enzym. Sie katalysiert den Transport von Kalziumionen aus der Zelle und besitzt gegenüber Kalzium eine hohe Affinität jedoch geringe Transportkapazität. Trotz der guten biochemischen Charakterisierung …
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Structural studies of the mitochondrial F-ATPase
The mitochondrial F-ATPases make about 90% of cellular ATP. They are multi-protein assemblies with a membrane extrinsic catalytic domain attached to a membrane embedded sector. They operate by a mechanical rotary mechanism powered by an electro-chemical gradient, generated across the inner …
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Atpase and Protein Kinase in Membranes From Corn Roots: Regulation of Tonoplast Atpase by Calmodulin or by Protein Kinase
A study was conducted to find if microsomal H('+)-ATPases from corn roots are regulated by Ca('2+)- or calmodulin (CaM)-dependent protein phosphorylation. This work included: (a) identifying the microsomal H('+)-ATPases; (b) characterizing protein kinase and phosphatase activities in microsomal …
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Thermodynamic effects of phospholamban on Ca-ATPase kinetics
The Ca-ATPase of sarcoplasmic reticulum removes cytosolic calcium to promote muscle relaxation. In the heart, the Ca-ATPase is regulated by phospholamban, which inhibits the Ca-ATPase by decreasing Ca-ATPase calcium sensitivity. However, the kinetic and thermodynamic mechanisms of inhibition are …
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Targeting the calcium ATPase to the endoplasmic reticulum
The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from the<br/>cytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removing<br/>excess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located in<br/>both the ER and the ER-Golgi …
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
<p>The dysregulation of AAA (ATPases associated with diverse cellular activities) mechanoenzymes has been linked to diseases, and chemical inhibitors and activators can be powerful tools to probe mechanisms and test therapeutic hypotheses. However,the structural conservation across the AAA protein …
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Regulation der vakuolären H(+)-ATPase durch reversible Proteinphosphorylierung
Die vakuoläre Protonen-ATPase, kurz V-ATPase, ist ein multimerer Enzymkomplex, der in fast jeder eukaryotischen Zelle zu finden ist und den aktiven elektrogenen Transport von Protonen über Membranen katalysiert. Die Aktivität der V-ATPase ist essentiell für eine Vielzahl physiologischer Prozesse. …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… I have explored the role of the vacuolar H+-ATPase (V-ATPase), the major proton pump for acidifying intracellular vesicles and facilitating lysosomal degradation, in regulating HIF-$\alpha$ turnover. Unbiased forward genetic screens in near-haploid human cells identified that disruption of …
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The effects of force on actin-myosin ATPase activity
… they generate movement through the actin-myosin ATPase reaction. However, the chemical reaction underlying movement remains unclear. Specifically, little is known about how the forces generated by muscle influence the chemistry of the force-generating reaction. We measured the effects of …
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Autoradiografische lokalisatie van Na+-K+-ATPase met 3H-ouabaine
Contains fulltext : mmubn000001_168227177.pdf (Publisher’s version ) (Open Access)
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Na,K ATPase, some aspects of structure and mechanism
Contains fulltext : mmubn000001_026999137.pdf (Publisher’s version ) (Open Access)
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Structural studies on the plant plasma membrane calcium-ATPase
The plasma membrane Ca$\sp{2+}$-ATPase is a ubiquitous membrane protein that mediates the active transport of calcium out of the cytoplasm into the cell exterior. In plant cells it is believed to play a major regulatory role in signal transduction by helping to maintain a large gradient of calcium …
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Physical Mechanisms of Ca-ATPase Regulation in the Heart
The Ca-ATPase is an integral membrane enzyme which translocates two calcium ions from the cytoplasm of the cell to the sarcoplasmic reticulum lumen utilizing ATP breakdown as its energy source, in order to promote muscle relaxation. The focus of this research is the cardiac isoform of the Ca-ATPase …
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Understanding PilB, The Type IV Pilus (T4P) Assembly ATPase
… the kinetics of PilB, the T4P assembly ATPase. PilB crystal structure exhibits an elongated hexamer with 2-fold symmetry indicating a symmetric rotary mechanism model. Except for its structure, the symmetric rotary mechanism of PilB has not been demonstrated experimentally. Its …
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Study of the Yeast Vacuolar-type ATPase by Electron Cryomicroscopy
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that use energy from hydrolysis of adenosine triphosphate (ATP) to pump protons across membranes and control the pH of many intracellular compartments. ATP hydrolysis in the soluble catalytic region of the enzyme is coupled to proton …
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Structural and Functional Characterization of the Putative Pineal ATPase PINA
… disposal, and many other functions. Copper ATPases (Cu-ATPases) are a family of enzymes facilitating copper transport in the body. ATP7B is one of them, and it belongs to a P-type class of ATPases. In 1999, an mRNA of a splice vari-ant (PINA) has been discovered in rat pineal gland and …
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