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Showing 1 to 1 of 1 for “"ATP7B gene"”.
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… in the P-type ATPase copper transporting B (ATP7B) gene, responsible for copper supply to cuproproteins and removal of excessive copper by biliary excretion. In ATP7B-knockout cells, copper overload triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating …