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Showing 1 to 9 of 9 for “"ATP7B"”.
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HSP70 as a Target for Correction of Wilson Disease Causing ATP7B Mutants
… the body is driven be Cu-transporting ATPase ATP7B, which sequesters the potentially toxic metal and mediates its excretion into the bile. Mutations in the ATP7B result in Wilson disease (WD) that is caused by the toxic accumulation of Cu in the liver due to the loss of ATP7B function. The …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… in the P-type ATPase copper transporting B (ATP7B) gene, responsible for copper supply to cuproproteins and removal of excessive copper by biliary excretion. In ATP7B-knockout cells, copper overload triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating …
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Structural and Functional Characterization of the Putative Pineal ATPase PINA
… facilitating copper transport in the body. ATP7B is one of them, and it belongs to a P-type class of ATPases. In 1999, an mRNA of a splice vari-ant (PINA) has been discovered in rat pineal gland and retina. Transcription levels of the mRNA increase during the night and decrease during the …
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Proteinkonjugationen durch Kupfer-abhängige Formylglycin-generierende Enzyme zur Generierung von Antikörper-Wirkstoff-Konjugaten
… initially analyzed using a copper transporter ATP7B-deficient hepatocyte cell line (HepG2 ATP7B-KO). It has been hy-pothesized that the secretory route of the hFGE, its N-terminal domain with still unknown func-tion, and an interaction with the Golgi-permanent copper transporter are involved in …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… v as shown to use copper transporter hCTR1 and ATP7B for influx and efflux respectively. Organic cation transporters (OCT) did not play an important role in BBR3464 cellular uptake, however, desipramine, an OCT inhibitor had synergistic effects on platinun drugs-induced cytotoxicity. This effect …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… coordinate copper uptake (CTR1, HAH1, ATP7A and ATP7B). However, copper uptake was increased by both acute (15 min) and chronic (16 h) berry extract treatment.<br/>Thus overall, there is a clear effect of flavonoids on the pathways of glucose, iron and copper and a possible interactive effect …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… expressing either ATP7A or CTR1, but not both or ATP7B. Neurons expressing the copper influx transporter, CTR1, were more susceptible to oxaliplatin-induced neurotoxicity compared to neurons expressing the copper efflux transporter ATP7A. Based on the abovementioned findings, a series of compounds …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… anhydrase IX and cupper transporters (Ctr-1 and ATP7B) was performed. In FaDu model we confirmed the same [64Cu]ATSM distribution at the two analyzed times, that is similar to that of [18F]FAZA. On the contrary, EMT-6 and PC-3 models showed a time-dependent [64Cu]ATSM uptake, with a distribution …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… to cisplatin in vivo. ATP7A and its homolog ATP7B are thought to confer chemoresistance by sequestering drugs in vesicles or the TGN, although the precise mechanisms remain under debate. The second part of this dissertation investigates the roles of ATP7A functions in the development of …