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Showing 1 to 6 of 6 for “"ATP7A"”.
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Therapeutic targeting of the ATP7A copper transporter in cancer
… cellular Cu uptake, while the P1B-type ATPase ATP7A facilitates Cu transport from the cytosol into the lumen of vesicles or the trans-Golgi network (TGN), where it metalates cuproenzymes such as the lysyl oxidase (LOX) family and tyrosinase. Under elevated Cu conditions, ATP7A undergoes …
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THE REGULATION OF THE INTESTINAL COPPER EXPORTER IS COORDINATED WITH SYSTEMIC COPPER HOMEOSTASIS
… in C. elegans. Moreover, we show that CUA-1, the ATP7A/B homolog in worms, localizes to lysosome-like organelles (gut granules) in the intestine under Cu-overload conditions for Cu detoxification, while Cu-deficiency results in a redistribution of CUA-1 to basolateral membranes for Cu efflux to …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… subsets of neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B. Neurons expressing the copper influx transporter, CTR1, were more susceptible to oxaliplatin-induced neurotoxicity compared to neurons expressing the copper efflux transporter ATP7A. Based on the abovementioned …
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Mechanisms of Copper Deficiency in the Zebrafish Embryo
… caused by loss-of-function mutations in <italic>ATP7A</italic>, a copper transport protein. Despite the critical requirement for adequate copper nutrition and the characterization of key copper transport proteins there remain significant gaps in our understanding of copper metabolism. In order to …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… genes that coordinate copper uptake (CTR1, HAH1, ATP7A and ATP7B). However, copper uptake was increased by both acute (15 min) and chronic (16 h) berry extract treatment.<br/>Thus overall, there is a clear effect of flavonoids on the pathways of glucose, iron and copper and a possible interactive …
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Application of copper isotope abundance measurements to study copper trafficking in vivo
… a protein responsible for copper import, and ATP7A, a protein responsible for copper efflux, were significantly down-regulated in antibiotic-treated mice.