Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"ATP-binding cassette transporters"”.
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Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie
… ergibt die Struktur eines typischen Volltransporters mit zwei Membrandomänen und zwei Nukleotidbindungsregionen (ABC-Kassetten). Anhand von Northern-Blot-Analysen konnte gezeigt werden, dass das humane ABCA5-Gen am stärksten im Skelettmuskel, der Niere, Leber und der Plazenta exprimiert …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
The aim of this project was to study ATP binding cassette (ABC) transporters in the human placenta, in particular their regulation and role in trophoblast differentiation and survival. The presence and localisation of four major placental drug transporters, multidrug resistance gene product 1 and 3 …
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Characterizing the role of ATP-binding cassette transporters in triterpenoid wax bloom production
… have yet to be fully elucidated. Numerous ATP-binding cassette (ABC) transporters have been characterized in model systems and crops, and some members of the G transporter subfamily are linked to the production of epicuticular wax blooms. Many studies utilizing model systems focus on …
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The Roles of ATP-Binding Cassette Transporters G5 and G8 in Liver X Receptor-Mediated Sterol Trafficking
… expression of two target genes of LXRalpha , the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for the increase in sterol excretion, the decrease in fractional cholesterol absorption, and the increase in fecal neutral sterol excretion associated with LXR agonist treatment. …
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Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment
… equation and is mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across …
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Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
ATP binding cassette transporters use ATP to transport substances such as sterols, peptides, drugs and other toxins across membranes. Abcg2 is a member of the G family of transporters that was identified in breast cancer cells due to its ability to efflux chemotherapeutic drugs. Abcg2 can also …
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HEPATIC LIPID METABOLISM: THE ROLES OF ACAT2 AND ABCG5/G8 IN THE DEVELOPMENT AND PREVENTION OF DISEASE
… liver disease (NAFLD). Adenosine triphosphate (ATP) Binding Cassette transporters G5 and G8 (ABCG5/G8 or G5G8) form an apical membrane obligate heterodimeric protein complex that transports intracellular free sterols to bile or the intestinal lumen. Data are presented to show that transgenic …
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Learning the ABC's of Ribose Transport Using Biophysical Methods
<p>ATP-binding cassette transporters comprise a large superfamily of proteins that are involved in a variety of biological phenomenon, from bacterial metabolism to cellular homeostasis, antigen-presentation, and drug resistance. These proteins are implicated in a variety of clinically relevant …
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Single-Molecule Studies of CFTR Gating and Pharmacology
… its evolutionary relationship with other ATP-binding cassette transporters. However, direct correlations between the essential functions of CFTR and extant structures are lacking at present. Opening of CFTR's pore is regulated by phosphorylation- and ATP-dependent dimerization of its two …
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The Molecular Mechanism of the Escherichia Coli vitamin B12 Transporter BtuCD-F: Real-time Observation of the Transporter in Motion
… are open to cytoplasm in the resting state, and ATP binding induces a major conformational change resulting in opening of the TMDs instead to the periplasm. However, the crystal structures of BtuCD from E. coli and recent EPR spectroscopy studies indicate that this type II importer employs a …
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Characterization of the Reaction Cycle of MJ0796: A Model Archaeal Adenosine Triphosphate-Binding Cassette Transporter Nucleotide Binding Domain
Adenosine-triphosphate binding cassette (ABC) transporters couple nucleotide hydrolysis to vectorial transport of solutes across lipid bilayers. These proteins, found in all kingdoms of life, have been implicated in a variety of human genetic disorders and engender drug resistance in cancer cells …