Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ATP-binding cassette transporter A1"”.
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
ATP binding cassette transporter A1 (ABCA1) facilitates cellular free cholesterol and phospholipid efflux across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, …
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ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM
Apolipoprotein M (ApoM) and ABCA1 are both expressed in hepatocytes, but their impact on lipid metabolism remains poorly defined. ApoM binds to plasma HDL via its retained signal peptide and transports sphingosine 1–phosphate (S1P). We found that liver–specific apoM transgenic mice had …
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THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM
Hepatic ATP binding cassette transporter A1 (ABCA1) and apolipoprotein M (apoM) both have been shown to influence high density lipoprotein (HDL) metabolism. Hepatic ABCA1, a plasma membrane protein, functions to transport free cholesterol (FC) and phospholipids across the plasma membrane to …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… the second uses an adipose specific knock out of ATP Binding Cassette Transporter A1 (ABCA1) to study adipose cholesterol metabolism in mice.
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RARE ABCA1 VARIANTS FOUND ONLY IN AFRICAN AMERICANS AND HOW THEY AFFECT LIPID EFFLUX AND NASCENT HDL FORMATION
… of Tangier disease and subsequent discovery of ATP binding cassette transporter A1 (ABCA1) as the gene responsible for the disease has changed the study of lipoproteins due to almost non-existent levels of HDL-C and increased atherosclerosis in these subjects. The idea that HDL-C and …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… X receptor in a similar manner. In addition, ATP-binding cassette transporter a1 transcription, LXR-induced target gene, was increased by addition of either oxysterol or LXR agonist. Thus, I conclude that these effects are mediated by LXR/RXR heterodimers. Next, these inhibitory effects of …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… soluble amyloid beta as well as amyloid beta-binding molecules determine the onset and amount of amyloid beta aggregation, significant attention has been devoted to defining the molecular and systemic pathways that modulate amyloid beta synthesis and clearance in the brain. Extensive evidence …
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The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… Apolipo protein E knockout (Apoe-/-) mice and ATP binding cassette transporter A1(ABCA1) and ATP binding cassette transporter G1 (ABCG1) knockout (Abca1-/-Abcg1-/-) mice demonstrated that cellular cholesterol retention leads to Hematopoietic Stem and Progenitor Cell (HSPC) expansion that …