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Showing 1 to 20 of 85 for “"ATP-binding cassette"”.

  1. tissue-specific role of ATP binding cassette transporter A1 in atherogenesis

    BI, XINWake Forest University2013

    ATP binding cassette transporter A1 (ABCA1) facilitates cellular free cholesterol and phospholipid efflux across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, …

    wfu Repository record

  2. Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie

    Petry, Frauke2012

    Im Rahmen dieser Arbeit wurde mit ABCA5 aus Gesamt-RNA der humanen Hepatomzell-Linie HepG2 ein neues Mitglied der ABCA-Subfamilie aus der Superfamilie der ABC-Proteine isoliert und charakterisiert. Das ABCA5-Gen umfasst einen offenen Leserahmen (OLR) von 4926 bp und kodiert für ein Protein der …

    goettingen Repository record

  3. Regulation and functional significance of ATP binding cassette transporters in human placenta

    Evseenko, DenisResearchSpace@Auckland2008

    The aim of this project was to study ATP binding cassette (ABC) transporters in the human placenta, in particular their regulation and role in trophoblast differentiation and survival. The presence and localisation of four major placental drug transporters, multidrug resistance gene product 1 and 3 …

    auckland-ms Repository record

  4. Characterizing the role of ATP-binding cassette transporters in triterpenoid wax bloom production

    Abrahamson, Taylor2024

    … have yet to be fully elucidated. Numerous ATP-binding cassette (ABC) transporters have been characterized in model systems and crops, and some members of the G transporter subfamily are linked to the production of epicuticular wax blooms. Many studies utilizing model systems focus on …

    umn Repository record

  5. Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria

    Guffick, CharlotteUniversity of Cambridge2022

    Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …

    cambridge Repository record

  6. ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM

    Liu, MingxiaWake Forest University2013

    Apolipoprotein M (ApoM) and ABCA1 are both expressed in hepatocytes, but their impact on lipid metabolism remains poorly defined. ApoM binds to plasma HDL via its retained signal peptide and transports sphingosine 1–phosphate (S1P). We found that liver–specific apoM transgenic mice had …

    wfu Repository record

  7. Initial characterization of the ribosome-associated ATP binding cassette (ABC) protein YHIH from E. Coli

    Fischer, Jeffrey J., University of Lethbridge. Faculty of Arts and Science2007

    lethbridge

  8. The Roles of ATP-Binding Cassette Transporters G5 and G8 in Liver X Receptor-Mediated Sterol Trafficking

    York, Jennifer Lynn2010

    … expression of two target genes of LXRalpha , the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for the increase in sterol excretion, the decrease in fractional cholesterol absorption, and the increase in fecal neutral sterol excretion associated with LXR agonist treatment. …

    utswmed Repository record

  9. Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment

    Gulati, Sonia2011

    … equation and is mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across …

    columbia-diss Repository record

  10. Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA

    Tang, YakunUniversity of Cambridge2023

    … MsbA are two paradigms in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) …

    cambridge Repository record

  11. THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM

    Bashore, Alexander CusaWake Forest University2018

    Hepatic ATP binding cassette transporter A1 (ABCA1) and apolipoprotein M (apoM) both have been shown to influence high density lipoprotein (HDL) metabolism. Hepatic ABCA1, a plasma membrane protein, functions to transport free cholesterol (FC) and phospholipids across the plasma membrane to …

    wfu Repository record

  12. An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition

    Tangella, Lokeswari PrathyushaEdith Cowan University, Research Online, Perth, Western Australia2020

    … in the review in Chapter 1. Overexpression of ATP-binding cassette (ABC) transporters has been linked to multidrug resistance in numerous cancer types. These transporters expel the anti-cancer drugs out of the cell, thereby decreasing the intracellular concentration of the drug. In melanoma, …

    edithcowan Repository record

  13. Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution

    Robillard, Kevin Ryan2014

    … and allow systemic viral repopulation. ATP-binding cassette drug efflux transporters i.e., P-glycoprotein and breast cancer resistance protein, have been previously shown to efflux antiretroviral drugs at the level of blood-brain barrier (Dallas, et al., 2004a;Lee, et al., 2007;Lee and …

    toronto-retro Repository record

  14. Screening for purine transporters in S. aureus

    Sonpaveerawong, TothongThe University of Western Ontario2022

    … as an exogenous purine source. I identified an ATP-Binding Cassette transporter mutant that failed to grow under the selective purine transport conditions. Further growth characterization of the mutant revealed that the growth defect was not due to an inability to transport purines but rather to …

    uwo Repository record

  15. Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217

    Moodley, ClintonDepartment of Molecular and Cell Biology2011

    … multidrug resistance by the active hydrolysis of ATP were studied here. These genes belong to the ATP-binding cassette (ABC) family of efflux transporters.

    cape-town Repository record

  16. Study on interactions of new anticancer drugs and their utilization for modulation of multidrug resistance in solid tumors

    Budagaga, Youssif A YoussifUniverzita Karlova, Farmaceutická fakulta v Hradci Králové2024

    … farmakokinetické mechanismy, jako jsou ABC (ATP-binding cassette) efluxní transportéry a cytochromy P450 (CYP). Cílem této studie bylo prozkoumat interakce nových cílených léčiv proti NSCLC s ABC transportéry a CYP enzymy a definovat jejich roli v MDR. Popsali jsme několik nových cílených …

    charles-prague Repository record

  17. The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity

    Cuffe, Helen AnnWake Forest University2015

    … the second uses an adipose specific knock out of ATP Binding Cassette Transporter A1 (ABCA1) to study adipose cholesterol metabolism in mice.

    wfu Repository record

  18. Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv

    Slyško, MatúšUniverzita Karlova, Farmaceutická fakulta v Hradci Králové2025

    … main mechanisms of MDR is the overexpression of ATP-binding cassette (ABC) transporters. These are a group of transmembrane proteins that negatively impact the efficacy of chemotherapy by reducing the intracellular concentration of drugs through their efflux out of the cells. Inhibition of these …

    charles-prague Repository record

  19. RARE ABCA1 VARIANTS FOUND ONLY IN AFRICAN AMERICANS AND HOW THEY AFFECT LIPID EFFLUX AND NASCENT HDL FORMATION

    Martinez, JohnWake Forest University2017

    … of Tangier disease and subsequent discovery of ATP binding cassette transporter A1 (ABCA1) as the gene responsible for the disease has changed the study of lipoproteins due to almost non-existent levels of HDL-C and increased atherosclerosis in these subjects. The idea that HDL-C and …

    wfu Repository record

  20. The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis

    Wang, Mi2013

    … Apolipo protein E knockout (Apoe-/-) mice and ATP binding cassette transporter A1(ABCA1) and ATP binding cassette transporter G1 (ABCG1) knockout (Abca1-/-Abcg1-/-) mice demonstrated that cellular cholesterol retention leads to Hematopoietic Stem and Progenitor Cell (HSPC) expansion that …

    columbia-diss Repository record

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