Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ATP-Binding Cassette (ABC) transporter"”.
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MRP4-Dependent Regulation of Fibroblast Migration
… 4 (MRP4), is a member of the large family of ATP binding cassette (ABC) transporter proteins, that localizes to the plasma membrane and functions as a nucleotide efflux transporter and thus plays a pivotal role in the regulation of intracellular cyclic nucleotide dynamics. In our study we used …
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… resistance protein 1 (MRP1), a plasma membrane ATP-binding cassette (ABC) transporter, is associated with high-risk neuroblastoma. While it is known that MRP1 transports multiple neuroblastoma chemotherapeutic agents out of the cell in a glutathione (GSH)-dependent manner, the mechanism of …
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Protein expression in Fusobacterium nucleatum ATCC 10953 biofilm cells induced by an alkaline environment.
… findings showed that transport proteins such as ATP binding cassette (ABC) transporter binding protein was down-regulated while tripartite ATP-independent (TRAP) transporter binding protein was enhanced in the alkaline environment. ABC transporters require ATP hydrolysis for solute transport. In …
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The regulation of yeast homotypic membrane fusion by class C ABC transporters
… system that regulates cellular traffic. The ABC transporter superfamily is present in all organisms and is responsible for actively transporting a wide range of substrates across the lipid bilayer. Several class C ABC transporters interact with factors that are important in the fusion …
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Identifizierung und Charakterisierung des vakuolaren ABC-Transporters Mlt1p und der Phospholipase B Plb5p von Candida albicans
… zudem die Isolierung und Charakterisierung des ATP-Binding-Cassette-(ABC)-Transporter-Gens caMLT1 aus C. albicans. CaMlt1p zählt zur MRP/CFTR-Unterfamilie ATP-bindender Transportproteine, eine Proteinkategorie, die in diesem Pilz bislang noch nicht beschrieben wurde. Energiebetriebene …
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Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment
… equation and is mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across …
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Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis
… the novel major facilitator superfamily (MFS) transporter, herein named CpMDR1B, and an ATP-binding cassette (ABC) transporter, herein designated CpCDR1B, were all upregulated by CpMrr1 GOF. Our development of a promotor replacement method for C. parapsilosis and implementation of a barcoded …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… the major contributor of azole resistance. The ATP binding cassette (ABC) transporter genes CDR1 and CDR2 have been shown to be regulated by a zinc cluster transcription factor Tac1p. A gain-of-function mutation in the gene encoding this transcription factor is responsible for the overexpression …
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Charakterisierung eines neuen ATP-binding-cassette Transporters aus der ABCA-Subfamilie
Im Rahmen dieser Arbeit wurde mit ABCA5 aus Gesamt-RNA der humanen Hepatomzell-Linie HepG2 ein neues Mitglied der ABCA-Subfamilie aus der Superfamilie der ABC-Proteine isoliert und charakterisiert. Das ABCA5-Gen umfasst einen offenen Leserahmen (OLR) von 4926 bp und kodiert für ein Protein der …