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Showing 1 to 20 of 27 for “"ATP-Binding Cassette (ABC) Transporters"”.

  1. Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria

    Guffick, CharlotteUniversity of Cambridge2022

    Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …

    cambridge Repository record

  2. Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA

    Tang, YakunUniversity of Cambridge2023

    … MsbA are two paradigms in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) …

    cambridge Repository record

  3. Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv

    Slyško, MatúšUniverzita Karlova, Farmaceutická fakulta v Hradci Králové2025

    … main mechanisms of MDR is the overexpression of ATP-binding cassette (ABC) transporters. These are a group of transmembrane proteins that negatively impact the efficacy of chemotherapy by reducing the intracellular concentration of drugs through their efflux out of the cells. Inhibition of these …

    charles-prague Repository record

  4. The Roles of ATP-Binding Cassette Transporters G5 and G8 in Liver X Receptor-Mediated Sterol Trafficking

    York, Jennifer Lynn2010

    … expression of two target genes of LXRalpha , the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for the increase in sterol excretion, the decrease in fractional cholesterol absorption, and the increase in fecal neutral sterol excretion associated with LXR agonist treatment. …

    utswmed Repository record

  5. An investigation into the synergistic action of chemotherapy and photodynamic therapy in resistant skin cancers

    Nsole Biteghe, Fleury AugustinDepartment of Human Biology2015

    … different treatments and further investigate the ATP-binding cassette (ABC) transporters (ABCB5/1 & ABCG2) expression profile, before and after chemotherapeutic (DTIC) and combination therapy (DTIC+HYP-PDT) treatments.

    cape-town Repository record

  6. Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti

    Pham, Ngoc NhuVirginia Tech2016

    … action of anticholinesterase chemistries. The ATP-binding cassette (ABC) transporters are efflux proteins that assist in maintaining the BBB interface and serve as a first line of defense to mosquitocide exposures. To date, there are three subfamilies (ABC -B, -C, -G) of ABC transporters; …

    vt Repository record

  7. Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity

    Penneycard, Jessica MarieThe University of Edinburgh2016

    … glyburide). In the placenta a network of apical ATP-binding cassette (ABC) transporters facilitates the efflux of substances away from the fetus, thereby protecting the fetus from exposure to unwanted substances including medications such as metformin and glibenclamide. In this thesis, I have …

    edinburgh Repository record

  8. Characterizing the role of ATP-binding cassette transporters in triterpenoid wax bloom production

    Abrahamson, Taylor2024

    … have yet to be fully elucidated. Numerous ATP-binding cassette (ABC) transporters have been characterized in model systems and crops, and some members of the G transporter subfamily are linked to the production of epicuticular wax blooms. Many studies utilizing model systems focus on …

    umn Repository record

  9. Bioremediation of Trichloroethylene: Analysis of the Plant Gene Response to TCE and Characterization of a Novel TCE-Degrading Endophyte

    Kang, Jun Won2012

    … (GST), glycosyltransferases (UGT), and ATP-binding cassette (ABC) transporters are involved in TCE metabolism in poplar. The study found that poplar trees do have a genetic response to TCE and that many putative detoxification genes are differentially regulated. Previous studies …

    washington Repository record

  10. ABCB6 Is a Porphyrin Transporter with a Novel Trafficking Signal That Is Conserved in Other ABC Transporters

    Fukuda, Yu2016

    <p>The ATP-binding cassette (ABC) transporters play an important role as a barrier to protect cells from the accumulation of toxic xenobiotics and metabolites due to their ability to translocate a wide array of compounds across lipid bilayers. However, many ABC transporters, especially the ones …

    tenn-hsc Repository record

  11. Regulation and functional significance of ATP binding cassette transporters in human placenta

    Evseenko, DenisResearchSpace@Auckland2008

    The aim of this project was to study ATP binding cassette (ABC) transporters in the human placenta, in particular their regulation and role in trophoblast differentiation and survival. The presence and localisation of four major placental drug transporters, multidrug resistance gene product 1 and 3 …

    auckland-ms Repository record

  12. Probing the biology of liver fluke-flukicide interplay

    Clarke, NathanQueen's University Belfast2020

    … detoxification and regenerative processes. ATP-binding cassette (ABC) transporters are implicated in multidrug resistant cancers through the active export of drugs from cells. Twenty-four putative ABC transporter sequences were identified in the F. hepatica genome. Pharmacological inhibition …

    qu-belfast Repository record

  13. On the mechanisms of transport and energy coupling in ABC exporters

    Singh, HimanshaUniversity of Cambridge2018

    … issue. Amongst five known classes of membrane transporters, which play a huge role in multidrug efflux, primary-active ATP-binding cassette (ABC) transporters are ATP powered whilst secondary-active transporters utilize electrochemical ion gradients to drive substrate transport. Mechanistic …

    cambridge Repository record

  14. Structural Study of Disease Relevant ABC Transporters-Cystic Fibrosis Transmembrane Conductance Regulator and ABCA4

    Liu, Fangyu

    <p>ATP-binding cassette (ABC) transporters are primary transporters that utilize the energy from ATP binding and hydrolysis to transport substrates across membrane against their concentration gradients. Structurally, canonical ABC transporters consist of four subunits— two transmembrane domains …

    rockefeller Repository record

  15. An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition

    Tangella, Lokeswari PrathyushaEdith Cowan University, Research Online, Perth, Western Australia2020

    … in the review in Chapter 1. Overexpression of ATP-binding cassette (ABC) transporters has been linked to multidrug resistance in numerous cancer types. These transporters expel the anti-cancer drugs out of the cell, thereby decreasing the intracellular concentration of the drug. In melanoma, …

    edithcowan Repository record

  16. Structure and Mechanism of PCAT1, a Polypeptide Processing and Secretion Transporter

    Kieuvongngam, Virapat

    <p>ATP-binding cassette (ABC) transporters utilize the energy from ATP to transport substrates across biological membranes. Various ABC transporters perform diverse biological functions across all forms of life ranging from importing essential nutrients to exporting toxic drugs (Ford and Beis 2019; …

    rockefeller Repository record

  17. Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma

    Forde, SorchaUniversity of Cambridge2019

    … important regulator of SP survival by regulating ATP-binding cassette (ABC) transporters hinting towards future therapeutic applications. Due to the rarity of biopsy samples taken at relapse in paediatric B-NHL, resistance to chemotherapy was induced both in vivo and in vitro mimicking relapse. In …

    cambridge Repository record

  18. PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY

    Bu, Yiwen

    … in these multi-drug resistant sublines. ATP-binding cassette (ABC) transporters are critical multidrug resistant factors. We found that in the RITA-resistant sublines, multiple ABC transporter genes were upregulated, particularly the ABCC6. Further studies dissected that ABCC6 was …

    siu-theses Repository record

  19. Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.

    Baidoo-Kanneh, Juliet N.E.The Graduate School and University Center of The City University of New York2023

    <p>As the tenth leading cause of cancer death in the United States with a 6.8% five-year survival rate, glioblastoma multiforme (GBM) is a very deadly disease with a poor prognosis. Therefore, a curative treatment is in high demand. Among the widely used anti-metabolites (Chemotherapeutic agents, …

    cuny-grad Repository record

  20. Human host and malaria parasite genome variations to susceptibility to malaria

    Hordofa, HundaolDepartment of Clinical Laboratory Sciences2023

    … (UGT), solute carrier (SLC) transporters, ATP-binding cassette (ABC) transporters, thiopurine Smethyl transferase (TPMT), and N-acetyltransferases (NAT) were used. Pharmacogenes reported to affect antimalarial drugs were noted and their distribution analysed. Single nucleotide …

    cape-town Repository record

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