Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"ATP synthesis"”.
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The action of selenite on ATP synthesis in rat lens
… opacification was preceded by a 15% decrease in ATP content. Lens ATP did not fully recover to control concentrations by 11 days post-injection. A moderate correlation existed between lens weight and total ATP content in control lenses <r=O.509, n=153), but this relationship disappeared with …
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Nitrite and insulin lower the oxygen cost of ATP synthesis in skeletal muscle cells by pleiotropic stimulation of glycolysis
… that dietary nitrate may render oxidative ATP synthesis more efficient, but evidence is inconclusive at present. This thesis aimed to establish how nitrite (a reduced form of nitrate) affects the bioenergetics of cultured skeletal muscle cells. Comparison between the acute effects of …
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Studies on the Efficiency of Energy Conservation in the Initial Stages of Photophosphorylation
… up to generate a predictable lag in the onset of ATP synthesis. When membranes so incubated were illuminated by a train of single turnover flashes, ATP synthesis began long before the added Tricine could have been titrated.
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Purification and Characterization of the Cytochrome-O Containing Terminal Oxidase of Escherichia Coli
… proton gradient that can be used by the cell for ATP synthesis, locomotion and active transport of ions and molecules into and out of the cell.
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MFSD7C: A Solute Carrier Linking Heme and Calcium in Mitochondrial Energy Metabolism
… mitochondrial respiration, but decreased ATP synthesis. Using several different methods, we show that the loss of MFSD7C stimulates cellular thermogenesis. The soluble N-terminal domain of MFSD7C contains conserved heme-binding motifs and directly binds two molecules of heme. We show that …
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Bioenergetics of Methanococcus voltae: Possible role for a primary sodium pump in ATP formation
The mechanism of ATP formation has been characterized in a few methanogens. Evidence has been obtained in whole cells of Methanosarcina barkeri that ATP is synthesized via a chemiosmotic mechanism. Results obtained with protoplasts from Methanobacterium thermoautotrophicum also agree with a …
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Differentially expressed genes in aortic cells from atherosclerosis-resistant and atherosclerosis-susceptible pigeons
… it was not obvious whether insufficient ATP synthesis is preventing the WC aortic cells from performing their contractile function or if the lack of functional contractile elements in the WC causes the mitochondrial ATP synthesis to down regulate. Either way, energy production was …
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Inhibition of <em>Escherichia coli</em> ATP Synthase by Polyphenols and Their Derivatives.
… polyphenols on <em>Escherichia coli</em> ATP synthase to test (I) if the beneficial dietary effects of polyphenols are related to their inhibitory actions on ATP synthase, (II) if inhibitory effects of polyphenolic compound could be augmented through structural modifications, and (III) if …
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Mitochondrial dysfunction in hereditary optic neuropathies
… to relative control population. Since the ATP synthesis rate – severely reduced in LHON patients lymphocytes - is not affected by the SOD2 genotype, we concluded that SOD2 gene could modulate the pathogenicity of LHON mutations through a mechanism associated to an increase of reactive …
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Study of the Proton Pumping Mechanism of the Aa3-Type Cytochrome C Oxidase
… for other biological activities, for example, ATP synthesis. The molecular mechanism of proton pumping is not well understood.
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Identifying the mechanism of second proton release from the bc1 complex Qo-site
… which generates a proton-motive force used for ATP synthesis. It is widely accepted to operate according to a modified Q-cycle, but there is still debate over some aspects of the mechanism. We used the pH-sensitive dye neutral red to study the release of protons from the bc1 complex, with …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… to poor prognosis and metastasis. The ATP5A1 protein, a key component of mitochondrial ATP synthase, plays a central role in energy metabolism and is linked to cancer-specific metabolic alterations, including the Warburg effect. Polyphosphates (PolyP) emerge as critical modulators of …
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Proteomics Study of Pre-Harvest Sprouting in Wheat
… metabolism, stress response, redox regulation, ATP synthesis, and protein translation, during this untimely germination of the wheat embryo. Hierarchical clustering analysis revealed the expression pattern of proteins in each of the resistant and susceptible germplasm and relative abundance of …
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… decreased NADH-linked respiration and diminished ATP synthesis efficiency. Supporting this observation, CRC-related reductions in the mitochondrial proteome where predominantly localized to subunits of complex I. Furthermore, in models of chemically induced colitis, complex I-supported respiration …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
… protons across the membrane to sustain ATP synthesis. A crucial aspect of the pharmacology of complex I is drug-induced mitochondrial dysfunction, particularly its role in liver toxicity. Complex I inhibition causes an energy deficit and can lead to adverse changes in the status of the …
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Structural Characterization of F-type and V-type Rotary ATPases by Single Particle Electron Cryomicroscpy
Adenosine triphosphate (ATP) is the molecular currency of intracellular energy transfer in living organisms. The enzyme ATP synthase is primarily responsible for ATP production in eukaryotes. In archaea and some bacteria, ATP is synthesized by V-ATPase that is related to ATP synthase both in …
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Ankyrin Dependent Mitochondrial Function and Bioenergetics In The Heart
… from the ER/SR to the mitochondria to modulate ATP synthesis. Given that mitochondrial function and energy production are paramount to cardiovascular heath, the work in this thesis explores the role of AnkB in recruiting and tethering wolframin (Wfs-1), a novel ankyrin binding protein along with …
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Applications of Mass Spectrometry to Analysis of Prodiginines, Bioactivated Methylenedianiline Intermediates, and Hypoxia Induced Changes in the Zebrafish Skeletal Muscle Proteome
… are up-regulated to compensate for the loss of ATP synthesis in aerobic metabolism. The up-regulation of two spots identified as hemoglobin variants was also observed. These protein expression changes are consistent with a hypoxic response that enhances anaerobic metabolism or O2 transport to …
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