NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 29 for “"ATP depletion"”.

  1. Mitotic slippage by ATP depletion and its mechanism

    박, 윤연2016

    … checkpoints monitoring the amount of available ATP during G1 phase and G2 to M transition. However, it is still uncertain the existence of energy checkpoint during mitotic progression. In our hand, ATP depletion by the co-treatment with 2-deoxy glucose (2-DG) and sodium azide (NaN3) during …

    ajou Repository record

  2. Lkb1 Deficient Non-Small Cell Lung Cancer Cells Are Vulnerable to Energy Stress Induced By Atp Depletion

    Yang, Chao2014

    … (8-Cl-Ado) is a compound which depletes cellular ATP. In this study, we have identified that 8-Cl-Ado is a potential therapeutic agent for targeting tumors with LKB1 deficiency. To determine the role of LKB1 and 8-Cl-Ado in cellular metabolism, we generated isogenic cell lines with either LKB1 …

    uthsc Repository record

  3. An in vivo study of chromatin compaction in human cells

    Visvanathan, AshwatUniversity of Dundee2013

    … the second part of the thesis, I use ATP depletion, in vivo, as a model system to induce chromatin compaction in HeLa cells. Either inhibition of transcription, or inhibition of kinases, does not prevent this increase of chromatin compaction caused by ATP depletion. The ATP dependent …

    dundee Repository record

  4. Improving the Efficacy and Expanding the Application of NQO1-Bioactivated Therapeutics

    Moore, Zachary Ray2020

    … in devastating oxidative DNA damage and energy depletion in the form of ATP, NAD(H) and NADP(H) loss specifically in tumor cells. However, ß-lap suffers from inherent limitations shared by quinone therapeutics, most notably methemoglobinemia at high doses caused by non-specific oxidation of …

    utswmed Repository record

  5. Signal Processing in Bacterial Chemotaxis

    Smith, Jimmie Marquette

    <p>This study localized 1) the site of ATP utilization in the signal transduction pathway of bacterial chemotaxis and 2) the point of convergence of the methylation-independent systems of chemotaxis with the methylation-dependent system. The site of ATP utilization was localized at the CheY …

    loma-linda Repository record

  6. Drinking water disinfection by-products: toxicological impacts and biological mechanisms induced by individual compounds or as complex mixtures

    Jeong, ClaraUniversity of Illinois at Urbana-Champaign2014

    … iii) develop a single well microplate-based ATP-protein assay as a novel toxicity metric for DBPs, iv) investigate the occurrence and in vitro mammalian cell toxicity of DBPs in European drinking water samples collected from the site where epidemiological studies on reproductive outcomes were …

    uiuc Repository record

  7. Studies on the internalization and intracellular transport of horseradish peroxidase in Chinese hamster ovary cells

    Sullivan, Peter C.Virginia Polytechnic Institute and State University1985

    … μM), or substances which should deplete cellular ATP NaF/KCN (2 mM /1 mM), showed no inhibition of dissociation kinetics. A chase at 17℃ inhibited dissociation of HRP over the entire 30 minute period. This HRP binding site(s) appears unique to endocytic vesicles. A minimum of four steps in …

    vt Repository record

  8. Chemomechanics of attached and suspended cells

    Maloney, John MapesMassachusetts Institute of Technology2012

    … to be unaffected by adenosine triphosphate (ATP) depletion, showing that ATP hydrolysis is not the origin of fluidity in cells during deformation. However, ATP depletion does reduce the natural variation in hysteresivity values among cells. This finding, and the finding that changes in the …

    mit Repository record

  9. The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells

    Caneda-Ferrón, BNottingham Trent University2006

    Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction. This study analyses how these factors influence the various activities of the proteasome in SH-SY5Y human neuroblastoma …

    nott-trent Repository record

  10. Toxicity mechanism of anthropogenic water contaminants: drinking water disinfection by-products (haloacetic acids) and particle associated contaminants from sealcoats (polyaromatic hydrocarbons) in lake sediments

    Dad, AzraUniversity of Illinois at Urbana-Champaign2017

    … weaker inhibitors. MonoHAAs greatly reduced the ATP contents of the cells. Unlike monoHAAs, triHAAs increased the cellular ATP levels as compared to the negative controls. Exogenous pyruvate supplementation rescued cells from monoHAA-induced DNA damage and ATP depletion. These results confirmed …

    uiuc Repository record

  11. SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH

    Tang, Yong

    … phosphorylation was associated with cellular ATP depletion and overproduction of reactive oxygen species due to mitochondrial dysfunction involving the induction of MPT and loss of Δψ. In this context, mitochondria biogenesis was initiated to recover cellular energy homeostasis. Importantly, …

    siu-theses Repository record

  12. Untersuchungen zur in vitro Interaktion von Peroxisomen mit Mikrotubuli und der daran beteiligten Bindungsproteine

    Thiemann, MeinolfUniversität Heidelberg

    … Temperatur und pH beeinflußt. Die Zugabe von ATP, Kinasen, Phosphataseinhibitor oder Motorproteinen erhöhte die Bindung, während ATP-Depletion oder Mikrotubuli-assoziierte Proteine sie verminderte. Eine KCl-Behandlung der Peroxisomen reduzierte die Bindung, was durch Zugabe von dialysiertem …

    heid-diss Repository record

  13. Necrotic cell death: A novel outcome of BHPI-hyperactivation of the anticipatory unfolded protein response

    Livezey, Mara R.University of Illinois at Urbana-Champaign2019

    … but rather through necrosis initiated by ATP depletion. This death pathway includes rapid swelling of ERa+ cancer cells and release of arachidonic acid, and is downstream of calcium release from the endoplasmic reticulum (EnR). Interestingly, preliminary data suggests that necrotic …

    uiuc Repository record

  14. Spectral-domain optical coherence phase microscopy for quantitative biological studies

    Joo, Chulmin, 1976-Massachusetts Institute of Technology2008

    … effect of an anti-cancer drug, Colchicine and ATP-depletion on the intracellular dynamics of human ovarian cancer cells, and observed the modification in diffusion characteristics inside the cells. Based on the optical sectioning capability of SD-OCPM, quantitative phase imaging was performed …

    mit Repository record

  15. Energy levels and anaerobic endproducts in the brains of two species of teleost fish at death in anoxic water

    DiAngelo, Constance RoseVirginia Tech1986

    … brains had higher concentrations of glycogen, ATP, CrP, and glucose than control trout. With anoxia, bullheads showed a significant decrease in ATP, CrP, and glycogen with no change noted for glucose, ketone bodies (betaâ hydroxybutyrate and acetoacetate), or alternative anaerobic endproducts …

    vt Repository record

  16. Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα

    Mi, Jianjie, author, Bamburg, James R., advisor, Chen, Chaoping, committee member, Partin, Kathryn M., committee memberColorado State University. Libraries2012

    … or R21Q cofilin-RFP expressing neurons with ATP depletion for 30 min, or with either Aβd/t (250 pM) or TNFα (50 ng/ml; 2.9 nM) for 24 h. Neurons were fixed and immunostained with a primary antibody for cofilin and an Alexa 647 nm-labeled secondary antibody. The percent of rods in RFP …

    colostate Repository record

  17. Structural characterisation of V-ATPases by electron microscopy

    Domgall, Ines

    Vacuolar H+-translocating ATPases (V-ATPases) are fundamentally important proteins. They pump protons into the interior of most cellular endomembrane compartments at the expense of ATP. V-ATPases are comprised of a membrane-integrated proton-translocating part (V0) and a soluble catalytic part …

    freiburg-diss Repository record

  18. Mast Cell Histamine Release Induced by Portuguese Man-of-War (Physalia) Venom

    Flowers, A. Lester

    … of calcium, at different temperatures, and with ATP depleted and ATP supplied mast cells. Following treatment the samples were assayed fluormetrically for both released histamine and released lactate dehydrogenase, a cytoplasmic enzyme marker.</p> <p>Physalia venom causes the release of both …

    loma-linda Repository record

  19. Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation

    Kolamunne, Rajitha K.Aston University2010

    … In conclusion, mitochondrial O2-•, but, not ATP depletion is the major cause of apoptotic and necrotic cell death in cardiomyoblasts under 2% O2, 4h hypoxia, whereas apoptotic cell death under 10% O2, 4h, is due to NOS-dependent •NO. The management of ROS/RNS rather than ATP is required for …

    aston Repository record

  20. The effect of acute alcohol exposure on hepatic oxidative stress and function: prevention by micronutrients

    Everitt, H.E.University of Westminster2010

    … levels were not increased. This suggests that ATP depletion is preventing apoptosis initiation. Betaine supplementation prevented almost all of the alcohol-mediated changes, suggesting that the main mechanism behind alcohol-mediated liver damage is oxidative stress. Results using the hepG2 cell …

    westminster Repository record

Page 1 of 2