Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"ATP Citrate Lyase"”.
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MOLECULAR REGULATION OF ATP-CITRATE LYASE
ATP-citrate lyase (ACLY) is the major source of glucose-derived acetyl-CoA outside the mitochondria and is an attractive therapeutic target for metabolic disorders and cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
… breast cancer. Using this methodology, we found ATP-citrate lyase (ACLY) as a novel interacting protein of LMW-E (T1) in the cytoplasm. ACLY is a 125kDa homotetrameric enzyme that catalyzes cytoplasmic citrate to acetyl-CoA and oxaloacetate in the <em>de novo</em> lipogenesis pathway. End …
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The use of bempedoic acid in treating hypercholesterolemia
… upon activation reduces LDL-C by inhibition of ATP citrate lyase, has been thoroughly evaluated as one such therapy for treating hypercholesterolemia. Through a variety of clinical trials, bempedoic acid, formerly referred to as ETC-1002, has displayed efficiency as both a low-risk monotherapy …
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Effects of acute and chronic exercise on the activities of hepatic lipogenic enzymes in rats
… different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
… acetyl-CoA carboxylase alpha (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis. Furthermore, the loss of ACLY or ACC1 reduced the levels and activities of the oncogenic transcription factor ETV4. Silencing ETV4 also protected cells from …
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Phyisiological, genomic and metabolic characterization of the oleaginous yeast Papiliotrema laurentii UFV-1
… and a single copy gene for the enzyme ATP citrate lyase, which is a key enzyme for oleaginous yeasts. We have found genes from alternative pathways for the lysine and leucine degradation, which may be alternative sources of acetyl-CoA for lipids accumulation. Analysis of expression and …
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Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens
… acetyl co-A carboxylase alpha (ACCα), and ATP citrate lyase (ACLY). HS down-regulated the hepatic expression of lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC), but up-regulated adipose triglyceride lipase (ATGL). Although it did not affect growth performance, Noni …
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Metabolic Engineering of oleaginous yeast for the production of biofuels
… carboxylase (ACC), delta9-desaturase (D9), ATP citrate lyase (ACL), and diacylglycerol acyltransferase (DGA). A combinatorial investigation revealed the order of contribution to lipid overproduction (from strongest to weakest): DGA, ACC, D9, ACL. Scale-up batch fermentation of selected …
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… the hepatic Vmax activities of glucokinase,<br/>ATP-citrate lyase and total acetyl CoA carboxylase. None of these<br/>enzyme activities increased when hepatic fatty acid synthesis was stimulated<br/>by feeding in control rats or by feeding and insulin in diabetic<br/>rats. Feeding stimulated …
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Acetyl-CoA metabolism and human trophoblast differentiation
… pregnancy. This thesis investigates the role of ATP citrate lyase (ACLY), an enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic modifications. The hypothesis was that ACLY is essential for maintaining trophoblast stemness by providing a …
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Synthesis and degradation of rat liver malic enzyme and citrate cleavage enzyme
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… DCIS.com showed significantly higher level of ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC) and FAS than the normal non-tumorigenic stem-like cells obtained from MCF10A. The result was also confirmed by qRT-PCR and Western blot as well as in clinical specimens of DCIS by …
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Effects of dietary fat and protein from corn coproducts on growth, carcass characteristics, ruminal metabolism, and genomic regulation of marbling development in early-weaned beef cattle
… 1, thyroid hormone responsive SPOT14 protein, ATP citrate lyase, adiponectin, diacylglycerol O-acyltransferase homologue 2, fatty acid binding protein 4, fatty acid synthase, phosphoenolpyruvate carboxykinase 1, and stearoyl-CoA desaturase, as well as, serum leptin concentrations during the …