Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ATM signaling"”.
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Atm Signaling to Tsc2: Mechanisms and Implications For Cancer Therapy
<p>Ataxia telangiectasia mutated (ATM) is a critical component of the cellular response to DNA damage, where it acts as a damage sensor, and signals to a large network of proteins which execute the important tasks involved in responding to the damage, namely inducing cell cycle checkpoints, …
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Mechanisms of Telomere End Protection by TRF2
… activating various DNA damage response (DDR) signaling and double-strand break repair pathways. The need to suppress these DDR pathways at telomeres is known as the "end protection problem." The TRF2 subunit of shelterin is responsible for suppressing the ATM DNA damage response kinase, which …
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ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… response kinase Ataxia Telangiectasia Mutated (ATM) might regulate crossover number, particularly in juvenile mice that exhibit reduced crossovers, referred to as the juvenile paternal age defect. During meiosis, ATM is known to negatively regulate SPO11-generated DNA double-strand breaks …
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Replicative Senescence is ATM-Driven, Reversible, and Delayed by Reduced ATM Activity at Low Oxygen
… the nature of the activated DDR is unclear. ATM kinase activation at critically short telomeres has been implicated in the induction of senescence, suggesting that the shortest telomeres lack su]icient TRF2 to repress ATM signaling. However, ATM-deficient cells also undergo replicative …
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A hybrid multilayer error control technique for multihop ATM networks
… great interest lately in the utilization of the ATM technology for networks. Especially in recent years, wireless ATM has emerged. The wireless links are characterized by higher, time-varying error rates and burstier error patterns in comparison with the fiber-based links from which ATM was …
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Nonhomologous end-joining: TDP1-mediated processing, ATM-mediated signaling
… repair: end processing, and DNA repair kinase signaling. DNA end processing was investigated in a mouse model of hereditary spinocerebellar ataxia with axonal neuropathy (SCAN1), a congenital neurodegenerative disease. SCAN1 is caused by a homozygous H493R mutation in the active site of …
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Further Insight into the Two Functions of Telomeres: Determining the Role of Tankyrase1 in Telomere Length Regulation and Tin2 in Telomere Protection
… loss at chromatid ends. We show that the ATM signaling pathway is activated in response to the telomere dysfunction induced by loss of TIN2 from the TRF2 complex, suggesting that TIN2 assists TRF2 in suppressing ATM activation at telomeres.</p>
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Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… DNA repair. After chemotherapeutic drug treatment induces full-length GSDMD nuclear translocation, GSDMD interacts with nuclear protein PARP-1 to dramatically inhibit its DNA Damage Repair-related function, to act similarly like the PARP inhibitor Olaparib. My findings confirmed that GSDMD …