Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"ATG9"”.
-
Atg11 and Atg9 interaction in selective autophagy
… acts as a scaffold protein, interacting with Atg9, Atg1 and other Atg proteins. Our research focuses on finding mutations in Atg11 that specifically disrupt its interaction with Atg9 without affecting its dimerization or interaction with Atg1. We targeted residues 455-535 of Atg11 as a …
-
The study of two transmembrane autophagy proteins and the autophagy receptor, p62
… core which include two transmembrane proteins, ATG9 and VMP1. While ATG9 and VMP1 has been discovered for about a decade and half, the trafficking and function of these proteins remain relatively unclear. My work in this thesis identifies and characterises a novel trafficking route for ATG9 and …
-
The role of autophagy in arabidopsis thaliana during biotrophic and hemibiotrophic fungal infections
… In A. thaliana mutants, atg4a/b, atg5-1, atg9-1 and atg9-6 deficient for the autophagic response, virulence of E. cichoracearum was retarded whereas pathogenesis of C. higginsianum was accelerated. Taken together, these data suggest that the autophagy pathway is a potential host …
-
Molecular analysis of vesicle biogenesis during autophagy
… the formation of autophagosomes out of the PAS. Atg9 a transmembrane protein has been proposed to cycle between the PAS and a peripheral pool that may serve as a membrane source. In S. cerevisiae this pool has been described to colocalize in part with mitochondria. This was questioned in …
-
An investigation of the function of adaptor protein complex 4 (AP-4)
… expressed transmembrane cargo proteins, ATG9A, SERINC1 and SERINC3, were found to be mislocalised in AP-4-deficient cells. Two novel cytosolic AP-4 accessory proteins, RUSC1 and RUSC2, were also identified. Further proteomic analyses confirmed the interactions between these proteins. AP-4 …
-
The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
… another affected cargo is the autophagy protein ATG9, whose trafficking from the Golgi is increased in FAPP1 KD cells, thus resulting in a strong induction of autophagy. Besides the regulation of specific trafficking events, I found that the pool of PI4P controlled by FAPP1 recruits and promotes …
-
Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… targets, including the DENND4 family, EML3 and Atg9. The DENND4 proteins are guanine nucleotide exchange factors for Rab proteins, while Atg9 is a component of the autophagosome. Therefore, my findings indicate novel roles for 14-3-3s in regulation of intracellular membrane dynamics. My studies …