Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ATF6"”.
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The degradation of membrane proteins from the mammalian endoplasmic reticulum
… ER substrates. In mammalian cells, neither the ATF6-dependent response nor the IREltc-XBP-1-dependent response of the UPR was found to be essential for efficient degradation of TCRc, US2-, or US 11-catalyzed destruction of MHC class I molecules. Interestingly, the ATF6 response, but not the …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… serpins’ phase transition is promoted by the ATF6 branch of the unfolded protein response during ER stress, and overexpression of ER chaperones calreticulin and BiP promotes this solidification and increases the stiffness of the resultant protein matrix. Single particle tracking of ER proteins …
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Super Low Dose Endotoxin Exacerbates Low Grade Inflammation through Modulating Cell Stress and Decreasing Cellular Homeostatic Protein Expression
… levels of Site 2 Protease, reduced generation of ATF6 and its transcriptional target BiP. Taken together, our study reveal that super low dose endotoxin exacerbates low grade inflammation through increasing phosphorylation of HCK, inducing Golgi dysfunction, and decreasing BiP /homeostatic protein …
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Improving cancer therapy strategies via cellular stress and immune modulation
… on plasma membrane-localized TRPM4 which induces ATF6-mediate cell death. Immunohistochemical analysis of human OS tissues confirmed that TRPM4 is widely expressed, suggesting that a substantial subset of bone cancer patients may be responsive to ErSO-based therapy. The second component examines …
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Regulation of the unfolded protein response by GADD34 and CReP
… (PERK), activating transcription factor 6 (ATF6), and inositol-requiring ER-to-nucleus signal kinase 1 (IRE1). PERK activation leads to the phosphorylation of the α-subunit of the translation initiation factor eIF2α on Serine 51 in activating its function. EIF2α phosphorylation leads to …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… in WHCO1 cells. We also observed a decrease in ATF6 90 kDa protein and transient XBP-1 mRNA splicing. The activation of p38, JNK and ERK MAPK pathways in bisPMB treated WHCO1 cells was also observed. Furthermore siRNA mediated knock-down of CHOP abolished the anti-proliferative effect of bisPMB …
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Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development
… transmembrane sensors IRE-1, PERK/PEK-1, and ATF6/ATF-6. The molecular mechanisms and output of the UPR have been defined largely by exogenously inhibiting ER protein folding, either chemically or through overexpression of unfoldable mutant ER proteins, while genetic studies have implicated …
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STRUCTURAL ANALYSES OF TRANSCRIPTION FACTOR/DNA COMPLEXES: NFI-X AND NF-Y
… two cryo-EM structures of NF-Y in complex with ATF6 and two cryo-EM maps of NF-Y in complex with USF1 have been elucidated, demonstrating how NF-Y cooperates with these transcription factors to recognize composite DNA elements. These structures provide unprecedented insights into the cooperative …
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… including activating transcription factor 6 (ATF6), inositol-requiring 1 (IRE1) and PKR-like ER localized kinase (PERK). The UPR is largely a cytoprotective response and is thought to contribute to tumor survival in the face of inadequate nutrients and oxygen. Microarray analyses were …