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Showing 1 to 4 of 4 for “"ATF5"”.
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Mitochondrial Unfolded Protein Response Regulator Atf5 In Mitochondrial Targeted Therapies In Aml
… also induce activating transcription factor 5 (ATF5), a primary mediator of UPR<sup>mt</sup> in mammals. Thus, we hypothesized that inactivating the cell-protective UPR<sup>mt</sup> pathway, by inhibiting ATF5, could potentially sensitize AML cells to mitochondrial stress. Consistently, flow …
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The Transcription Factor ATF5 Protects Cortical Neurons from Toxicity Induced by Prostaglandin J2
… and Alzheimer’s disease. Transcription factor ATF5 has been shown to mediate an endogenous stress pathway known as the UPR<sup>mt</sup>, a prosurvival mechanism amidst malfunctioning mitochondria. However, the ATF5/UPR<sup>mt</sup> protective pathway associated with mitochondrial impairment in …
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The mechanisms regulating the transcription factor ATF5 and its function in the integrated stress response
… the expression of the transcriptional regulator ATF5 is enhanced in response to many different stresses, including endoplasmic reticulum stress, arsenite exposure, and proteasome inhibition, by a mechanism requiring eIF2 phosphorylation. ATF5 is regulated by translational control as illustrated …
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The Role of ATF5 in Mitochondrial Maintenance, Biogenesis and UPRmt Signaling Following Acute Exercise in Skeletal Muscle
… dependent on activating transcription factor 5 (ATF5) during mitochondrial dysfunction. Protein homeostasis can temporarily be disrupted by acute exercise, inducing the UPRmt. Using WT and whole-body ATF5 KO animals, we sought to determine the role of ATF5 in regulating basal mitochondrial …