Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"ATF4"”.
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Screens for non-eukaryotic initiation factor two alpha dependent activation of ATF4 translation
… a previously unknown pathway for activation of ATF4 translation that does not require phosphorylation of the classical ISR affector molecule eIF2α. I also show that mTOR signaling is not necessary for this activation of ATF4, and that this pathway is modulated by the genes METAP2 and OGT. Next, …
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The Role of ATF4 in Mediating Skeletal Muscle Function in Response to Acute Contractile Activity
… on the activating transcription factor 4 (ATF4). Mitochondrial homeostatic conditions can be challenged by acute contractile activity/exercise, activating the ISR. Using a mouse model, we sought to determine the responsiveness of the ISR and ATF4 to acute contractile activity of hindlimb …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… the ER stress inducible transcription factor ATF4. Specifically, we demonstrate that ectopic expression of ATF4 sensitizes neurons to ER stress induced apoptosis, and that ATF4-deficient neurons exhibit markedly reduced levels of PUMA expression and cell death. However, chromatin …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
… DISC1 interacts with the transcription factor ATF4, which is involved in the regulation of cellular stress responses and memory consolidation. Here I show that at basal cAMP levels, wild-type DISC1 strongly inhibits the transcriptional activity of ATF4, and this effect is ablated by 37W and …
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A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… induction of activating transcription factor 4 (ATF4), which also potentially play a role in autophagy related-genes expression. The present study investigates the mechanisms by which maternal protein restriction induce autophagy related-gene expression in the liver of offspring rats. In this …
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The investigation of the neuronal and synaptic defects in early stage of amyloid-beta pathology
… activates activating transcription factor 4 (ATF4), a molecular switch between pro-survival and pro-death pathways, whose upregulation in AD patients and mouse models suggests its involvement in this transition. In Chapter 3, we characterize the role of ATF4 in neuronal network activity and …
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The mechanisms regulating the transcription factor ATF5 and its function in the integrated stress response
… induction of preferential translation of ATF4. ATF4 is a transcriptional activator of genes involved in stress remediation, a pathway referred to as the Integrated Stress Response (ISR). We investigated whether there are additional transcription factors whose translational expression is …
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Postnatale Entwicklung des GABAergen Systems im Gehirn der Maus
… mit dem aktivierenden Transkriptionsfaktor ATF4 kolokalisiert. Während GABAB R1 und ATF4 ihre stärkste Interaktion zwischen P0 und P3 aufweisen, erreicht die Interaktionstärke von R2 und ATF4 ihr Maximum zwischen P8 und P15. Die hier dargestellten Ergebnisse unterstützen die Hypothese, daß …
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The effect of alternative splicing on key regulators of the integrated stress response
… of specific transcription factors, such as ATF4. ATF4 reprograms gene expression to alleviate stress damage; however, under chronic stress, ATF4 directs the transcriptional expression of CHOP, which can trigger apoptosis. Because multiple stresses can induce eIF2α phosphorylation and …
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Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia
… homeostasis. Activating transcription factor 4 (ATF4) acts as the master transcriptional regulator of the ISR by promoting the transcription of genes that mitigate stress or promote cell death if the stress remains unresolved. Despite being the common mediator of various stress response and …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… the FGF21-inducing transcription factor ATF4 from the AARE1 response element in the FGF21 promoter of acinar cells. Since ATF3 is induced by ISR activation in pancreatitis, therapeutic inhibition of the ISR is also effective but requires endogenous FGF21. Moreover, FGF21 is …
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The Essential Role of the Non-Essential Amino Acid Asparagine in Lymphoid Malignancies
… of activating transcription factor 4 (ATF4) to the promoter to drive ASNS transcription. Our follow-up study in ALL cells showed that asparagine bioavailability (through de novo biosynthesis or exogenous sources) is essential to maintain the expression of the critical oncogene c-MYC. …
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Role of microRNA 214 in cyclic stretch induced aortic valve pathogenesis
… of miR-214 and one of its well-known targets (ATF4) and downstream genes (CHOP and BCL2L1) in porcine AVs ex vivo. Also, the effect of miR-214 overexpression on porcine AV calcification is evaluated. This would give a better understanding on the potential therapeutic role of miR-214 in CAVD.
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Autophagy: activation, function and regulation by a protein restricted diet during pregnancy and lactation
… is the activating transcription factor 4, ATF4. It has been shown that ATF4 can regulate macroautophagy in response to amino acid limitation. The process of autophagy is essential for the maintenance of cellular homeostasis, and our results show that a gestational low protein (LP) diet …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… cell pool, and increased expression of Grp78, Atf4 and Atf6a UPR markers. The phenotype was partially rescued by addition of a chaperone to the culture medium. In conclusion, both the in vitro and in vivo models demonstrate that ER stress perturbs differentiation of TS cells at the blastocyst …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… cellular translational capacity via mTORC1 and ATF4, leading to enhanced global translation rate, cell growth, and production of inflammatory cytokines. Inhibition of OxPhos via myeloid-specific knockout of OPA1, which stimulates ETC complex assembly, exacerbates sepsis in mice while inhibition …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… expression of activating Transcription Factor 4 (ATF4). In addition, HIV-infected iMg showed an increase in the expression of ATF4, C/EBP Homologous Protein (CHOP), and Binding Immunoglobulin Protein (BiP) mRNA, consistent with partial activation of ISR. Inhibition of PERK via treatment with a …
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Converging biochemical pathways in psychiatric disorders
… of transcriptional repression by DISC1 on ATF4-mediated gene transcription. The second project presents some initial steps towards uncovering the role of BCL9 in neuronal development.
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Contribution of the Unfolded Protein Response to VEGF Expression
… Our studies on VEGFA regulation revealed that ATF4, a UPR-inducible transcription factor, bound to the mouse and human VEGFA promoters. Using a combination of mouse embryonic fibroblasts and human neuroblastoma cell lines that are deficient in this transcription factor, we demonstrated that …
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New Roles for the Integrated Stress Response in Cancer and Proteostasis
… reporters for alternative translation (Atf4-firefly) and housekeeping translation (HBB-renilla) we performed a high throughput screen and have identified promising hits with potential as novel EIF2A inhibitors. </p>
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