Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"ATF3"”.
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… and function, specifically of IRF1 and ATF3 in corneal epithelial cells to elucidate the transcriptional mechanisms underlying the protective function of flagellin on the cornea. </p> <p>Initially we used Superarray to screen for transcription factors and identified Interferon Regulatory …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
… the metastasis promoting transcription factor, ATF3, as a downstream target of NDRG1. Further analysis revealed that the KAI1 promoter contained a consensus binding motif of ATF3, suggesting a possibility that NDRG1 suppresses metastasis through inhibition of ATF3 expression followed by …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… binding of the transcriptional repressor ATF3 that displaces the FGF21-inducing transcription factor ATF4 from the AARE1 response element in the FGF21 promoter of acinar cells. Since ATF3 is induced by ISR activation in pancreatitis, therapeutic inhibition of the ISR is also effective but …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… factors activating transcription factor 3 (ATF3), and JUN proto-oncogene (JUN), as key regulators of the adipose eosinophil gene program. Using an immortalised human eosinophil cell line (EoL-1 cells), we found that ATF3 is involved in suppressing the inflammatory response while promoting …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… factors (TFs) including Fos, Junb, Egr1 and Atf3. Interestingly, these 4 TFs showed upregulation in normal proximal tubule (PT) cells as mice get older. The second wave showed upregulation of Sox4 and Sox9, which are involved in kidney epithelial cell regeneration. Single cell ATAC sequencing …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… factor. Additionally, we have observed that ATF3 weakly binds to the CH25H promoter, suggesting co-operation with STAT-1. However, ZIKV induced CH25H was independent of type I interferon. Conclusion This study has demonstrated for the first time that pro-inflammatory cytokines such as 1L-1, …
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A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… of the stress- response genes including Atf3 and Chop in liver of female offspring, but not in male. Moreover, mRNA expression of hepatic autophagy gene including LC3b, P62/SQSTM1, Beclin1, Atg3, Atg7, Atg5, and Atg10 was increased significantly only in the female offspring by gestational …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… immediate early genes (IEGs) activating the ATF4-ATF3 stress response pathway. Notably, changes in serotonin dynamics, including increased levels and serotonylation, were observed, suggesting that serotonylation may regulate cellular stress responses and contribute to cell proliferation during …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… of negative regulators of innate immunity (ATF3, TRIB3, DUSP1) and through changes in global histone acetylation patterns, events important in maintaining immune regulation. THP-1 human monocytes conditioned with the LrS showed functional, transcriptional, and immunometabolic signatures …
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Hemmung der humanen Telomerase Reverse Transkriptase-Expression mittels synthetischer Nukleinsäuren in Harnblasenkarzinomzellen
… zellulären Stressantwort assoziiert sind (u.a. ATF3, EGR1, GADD45). Diese Expressionsmuster stimmten in hohem Maße mit denen überein, die durch Transfektion mit AS-ODN gegen andere Targets erhalten wurden. Diese Ergebnisse deuten auf eine, zumindest teilweise, durch off-Targeteffekte ausgelöste …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
PART I Differential expression of genes according to colchicine responsiveness in Behçet’s disease Behçet disease (BD) is a chronic relapsing, systemic inflammatory disorder which is treated with colchicine. However, some patients are not responsive to it. In this study, I wanted to explore the …