Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"ATF2"”.
-
Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis
INTRODUCTION: ATF2 belongs to the AP1 transcription factor family that homodimerize or heterodimerize with other members of the bZIP family and regulates the transcriptional activation of target genes. Previous studies have shown that ATF2 mediates VEGF-induced angiogenic processes but the …
-
Heterologous expression of alcohol acetyltransferase genes in Escherichia coli and Clostridium acetobutylicum for the production of esters
… in C. acetobutylicum . The genes ATF1 and ATF2, encoding AATase I and AATase II from the yeast Saccharomyces cerevisiae, and SAAT encoding a strawberry alcohol acetyltransferase, Saatp, have previously been sequenced. Biochemical studies have shown them to possess AATase activity. For this …
-
The Sec6/8 (a.k.a. Exocyst) Complex Supports DNA Repair Fidelity
… restraint of the associated chromatin modifiers ATF2 and RNF20. Exocyst perturbation resulted in aberrant accumulation of ATF2 and RNF20; the promiscuous accumulation of DDR-associated chromatin marks; and IR-induced increased Rad51 repairosomes. Thus, the exocyst indirectly supports DNA repair …
-
Inhibition of IFN-[gamma] promoter function by site-specific methylation
… Methylation at this position inhibits c-Jun, ATF2 and CREB binding in vitro. Consistently, the same factors bind to the unmethylated promoter in a TH1 cell line, but not the methylated promoter in a TH2 cell line. Furthermore, methylation of the proximal promoter at the -53 position alone is …
-
An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… tumour metastasis. Here it was determined that ATF2 is a downstream molecule activated (phosphorylated) by major pro-angiogenic factors and that its suppression in HUVECs resulted in increased upregulation of Notch signalling pathway (major regulator of angiogenesis) ligand DLL1 and DLL4. …
-
A Mechanism for the Metabolic and Inflammatory Alterations Associated with Low-dose Endotoxemia
… of pro-inflammatory transcription factor ATF2. Overall our studies point to several mechanisms of cross-talk between metabolism and inflammation and offer significant support to the concept of metabolic endotoxemia in the development of chronic disease.
-
Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… of activating transcription factor 2 (ATF2) and the persistent recruitment of C/ebpδ to the IL-6 promoter. In the third study, the molecular mechanisms that mediate LPS-induced priming was examined. The results demonstrate that macrophages are able to sense their prior history of …
-
Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
… <em>QDR2, YBT1</em>), lipid metabolism (<em>ATF2, ARE1</em>), cell stress (<em>HSP12, CTA1</em>), DNA repair (<em>YIM1, MEC3</em>) and cell wall function (<em>MKC7, MNT3</em>). These azole resistance-associated changes could affect <em>C. glabrata</em> tissue-specific virulence; in support of …
-
Isolation and Characterisation of Yeasts with Biotechnological Properties
… (AATase) encoding genes ATF1 and ATF2 are present, both K. aerobia and K. servazzii have only one orthologue in their genome. This study will expand the knowledge on the application of non-Saccharomyces yeasts in winemaking, particularly Kazachstania spp. which have demonstrated …