Global ETD Search
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Showing 1 to 3 of 3 for “"AT7519"”.
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… injury model to test whether CDK9 inhibitors, AT7519 and Flavopiridol (FVP), resolve neutrophil infiltration and whether this regulates downstream macrophage involvement and cardiac repair/regeneration. AT7519 and FVP were found to enhance the resolution of neutrophilic inflammation by inducing …
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Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation
… a novel cyclin-dependent kinase (CDK) inhibitor (AT7519) to resolve the acute neutrophil-mediated inflammatory response to stenting without adversely affecting the function and integrity of the endothelium. MethodsIn 49 patients with acute myocardial infarction atherothrombotic specimens were …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
… multi-CDKs inhibitors Dinaciclib, SNS-032, and AT7519, as well as that of the CDK1-cyclin B1 inhibitor Cucurbitacin E, on cell proliferation, viability, and apoptosis; lastly, 3) the combinatorial effect of Plogosertib and Dinaciclib on ACC cells proliferation. Experiments were carried out in …