Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"AT2R"”.
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… treatment with angiotensin-II type 2 receptor (AT2R) agonist C21 rescues megalin surface expression in the proximal tubules potentially by activating Akt-mediated phosphorylation and inactivation of GSK3β in the kidney of male obese Zucker rats fed HSD for 48 hrs. The HSD intake resulted in …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated pregnant rats; hypoxic-ischemic encephalopathy (HIE) in 10-day-old rat pups. In the first part …
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Zusammenhang zwischen Therapieergebnis und genetischen Polymorphismen in der Behandlung adipöser Kinder
… Genen der Renin-Angiotensin-Achse (ACE, AT1R, AT2R), sowie insgesamt vier Polymorphismen in Genen des beta-adrenergen Systems (ADRB2, ADRB3, BUP),untersucht. Die untersuchten Polymorphismen im ACE, AT1R, ADRB3 und BUP-Gen zeigten keinerlei Zusammenhang zu den Therapieergebnissen. Die …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… receptors in addition to the AT1R, such as the AT2R and Mas receptor, may have negative consequences. Previously identified genetic variants in the gene encoding smooth muscle alpha-actin, ACTA2, were modeled with Acta2-/- mice. I found that the ascending aorta and aortic root in these mice …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… structure and focusing on the roles of AT1R and AT2R, while the brain development will also be affected by this maternal insult increasing the vulnerability of this to HIE brain injury and the role of GR and the epigenetic modification that regulate the expression of the GR will be assessed. …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… angiotensin (1-7), angiotensin type 2 receptor (AT2R), and the Mas receptor. The Mas receptor (MasR) is widely expressed on various tissues within the body, specifically in neurons, astrocytes, and microglia within the central nervous system (CNS). Within the CNS, MasR activation reduces many of …