Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AT2 receptor"”.
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… revealed that Ang II, acting primarily through AT2 receptor activation of the protein phosphatase 2A (PP2A), attenuated NMDA-mediated increases in extracellular regulated kinase-2 (ERK-2) activity. We have identified that AT2 receptor activation inhibits cleavage of the DNA repair enzyme …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese animal and contribute to natriuresis. However, the role of AT2 receptors in oxidative stress and inflammation is not well studied. On the other hand, oxidative stress …
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A Structural and Functional Analysis of the Human Angiotensin II Type-2 Receptor
… of the cytoplasmic loops and tail of the AT 2 receptor are used to determine what regions are important to G-protein activation. These studies will map the G-protein coupling regions of the human AT2 receptor and develop a wider understanding of AT2 receptor/G-protein interactions.
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Angiotensin's Role in Hypoxic Injury
In order to determine the mechanism in which the AT2 receptor protected cortical neuronal cultures from sodium azide-induced apoptosis. We show that K+ channels are required for AT2 receptor neuroprotection and more specifically the actions of the delayed rectifier K+ channel. We suggest that the …
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The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… patterns of NOS isoforms, renin, and AT1 and AT2 receptors in immature preglomerular resistance microvessels utilizing novel microdissection techniques; and (4) determine AII regulation of NOS expression and function in the immature renal vasculature using AT1 and AT2 receptor inhibitors.</p> …
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… Expressions of myofibroblasts and Ang-II receptors (AT1 and AT2) within breast capsule tissue were also investigated using immunohistochemistry. The results show that myofibroblasts were present in all capsules (n=12). Ang-II receptors were present in 50% (n=6) of capsules (paraffin and …
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Investigating novel therapeutic targets for treatment of visceral pain.
… effect was inhibited by angiotensin AT1 but not AT2 receptor antagonists indicating that Ang II may contribute to the production of abdominal pain in IBD through the activation of AT1 receptors. MMP1 caused a marked increase in intracellular Ca2+ in DRG neurons classified as nociceptors by their …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of the massive …