Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"AT1R"”.
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EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
… cytokine via its Ang II type 1 receptor (AT1R), (3) the brain has its own intrinsic RAS, and (4) AT1R blockade, by oral administration of the AT1R antagonist L-158,809, ameliorated impairment in the novel object recognition task after fractionated WBI. The work in this dissertation tested …
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Engineering the angiotensin II type 1 receptor for structural studies
… to engineer the angiotensin II type 1 receptor (AT1R), a human GPCR, to make it suitable for structural studies. It was determined that detergentsolubilised AT1R was thermostable with antagonist bound with an apparent Tm of ~45°C, which was sufficiently stable for purification without further …
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Effect of Thyroid Hormones on AT1R MRNA Levels in HEK 293 Cells: Implications for Early-Onset Hypertension in Children Born of Preeclamptic Women
<p>This experiment tested the effect of thyroid hormones, T3 or T4, on angiotensin II type 1 receptor mRNA levels in human embryonic kidney cells (HEK). Maternal preeclampsia is a prediction of higher ambulatory blood pressure (ABP) in the exposed offspring. The mother's blood pressure affects the …
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Investigating the role of the Renin Angiotensin System in cancer
… specifically the Angiotensin Type 1 Receptor (AT1R) for its function. In this study, we investigated the potential association of the endogenous ACE-1 and ACE-2 enzymes in cervical cancer. Our results showed that ACE-1 and AT1R protein expression was elevated in cervical cancer cell lines …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse models. I set out to better understand the relationship between angiotensin and TAAD in our mouse models, and hypothesized that …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
… through the angiotensin II type 1 receptor (AT1R), a heptahelical membrane protein coupled to trimeric G-proteins on the cytosolic side. AT1R on binding its ligand, Ang II, leads to downregulation of cell-surface receptor and also its mRNA. We have investigated whether the 3'- and …
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Angiotensin II signalling in sensory neurons
… II was mediated by the Type I Ang II receptor (AT1R). Conversely, the response of IB4-negative neurons to Ang II did not require AT1R but did require the presence of non-neuronal satellite cells. Ang II-evoked Ca2+ signals downstream of AT1R were mediated by Ca2+ release from intracellular …
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Zusammenhang zwischen Therapieergebnis und genetischen Polymorphismen in der Behandlung adipöser Kinder
… in den Genen der Renin-Angiotensin-Achse (ACE, AT1R, AT2R), sowie insgesamt vier Polymorphismen in Genen des beta-adrenergen Systems (ADRB2, ADRB3, BUP),untersucht. Die untersuchten Polymorphismen im ACE, AT1R, ADRB3 und BUP-Gen zeigten keinerlei Zusammenhang zu den Therapieergebnissen. Die …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated pregnant rats; hypoxic-ischemic encephalopathy (HIE) in 10-day-old rat pups. In the …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… kidney structure and focusing on the roles of AT1R and AT2R, while the brain development will also be affected by this maternal insult increasing the vulnerability of this to HIE brain injury and the role of GR and the epigenetic modification that regulate the expression of the GR will be …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… II (Ang II)-angiotensin type 1 receptor (AT1R) and the Ang-(1-7)-AT7-MasR pathways that generally oppose the actions of one another. Although AGE-RAGE activation may stimulate the Ang II-AT1R axis, the role of Ang-(1-7) in AGE-induced EMT in the kidney is not known. The present study …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… and the angiotensin type 1 receptor (AT1R). When this arm is activated, it is known to increase oxidative stress and inflammation. Using a medical informatic approach, we found that blocking AT1R activation, through ACE inhibitors and angiotensin receptor blockers (ARB), was associated …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… induces oxidative stress in the PVN through an AT1R mediated mechanism in CHF, and offers new insight into the sympathoexcitatory mechanisms in the brain possibly involved in the pathogenesis of CHF.
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… the roles of angiotensin II type 1 receptors (AT1R), insulin receptors, and N-methyl-D-aspartate receptors (NMDAR) on TRPC6 activity are studied here. In acutely isolated rat glomeruli, angiotensin causes an upregulation of TRPC6 activity, and this is mediated by the Gαq /PLC pathway. This …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… in DETC-treated cells, which was attenuated by AT1R blocker candesartan and SOD-mimetic tempol. Results from animal studies (SD rats) suggest that DETC treatment increased systolic and diastolic blood pressure, which were attenuated with tempol treatment. Furthermore, DETC treatment increased …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
… which was comparable to angiotensin AT1R. The A<sub>2B</sub>R agonist BAY and the A<sub>2A</sub>R agonist CGS both increased ERK and CREB phosphorylation. BAY and CGS effects on signaling were blocked by deletion of A<sub>2B</sub>R and A<sub>2A</sub>R, respectively. TGFβ-induced …
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Preeclampsia: The Roles of Acute Inflammation and Intrauterine Stress
… decreased global methylation of renal DNA and AT1R promoter, in offspring born to PE mothers are conserved across generations. When combined with an additional environmental stimulus, these changes result in hypertension. These finding posit novel mechanisms for the etiology of hypertension and …