Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"AT1 receptors"”.
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… to IL-11 expression and AA development via AT1 receptors and PIEZO1 channels. METHODS: To simulate these BSMKO conditions, aortic VSMCs were pharmacologically treated with AngII and Yoda1. This treatment is expected to enhance calcium influx via AT1 receptors and PIEZO1 channels, resulting …
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… Expressions of myofibroblasts and Ang-II receptors (AT1 and AT2) within breast capsule tissue were also investigated using immunohistochemistry. The results show that myofibroblasts were present in all capsules (n=12). Ang-II receptors were present in 50% (n=6) of capsules (paraffin and …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of the massive …
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Vascular receptor changes in ischemic stroke
… accompanied by an increased expression of ET(B) receptors. 2. Organ culture of rat MCAs induces a time-dependent upregulation of contractile ET(B) receptors. The phenomenon is due to de novo transcription of the receptors and is partly dependent on PKC. 3. bFGF increases the ET(A) and ET(B) …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… designed to investigate the presence of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from primary tissue of 11 patients who had the disease. My hypothesis is that myofibroblasts will express angiotensin receptors and that these will primarily be of the AT1 receptor subtype. …
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Investigating novel therapeutic targets for treatment of visceral pain.
… This effect was inhibited by angiotensin AT1 but not AT2 receptor antagonists indicating that Ang II may contribute to the production of abdominal pain in IBD through the activation of AT1 receptors. MMP1 caused a marked increase in intracellular Ca2+ in DRG neurons classified as …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese animal and contribute to natriuresis. However, the role of AT2 receptors in oxidative stress and inflammation is not well studied. On the other hand, oxidative …
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The role of Toll-like receptors in Parkinson's disease
… aggregates, and may be mediated by Toll-like receptors (TLRs). TLRs are pattern recognition receptors with the ability to detect damage-associated molecular patterns. The activation of TLRs, potentially occurring through the detection of aggregated α-synuclein, triggers the release of …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… homeostasis in the body. Angiotensin II type 1 (AT1) receptor is the key component of RAS that is implicated in hypertension. Oxidative stress is considered one of the main causes of hypertension. Studies including in our own lab showed that oxidative stress increases renal AT1 receptor function …