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Showing 1 to 15 of 15 for “"AT1 receptor"”.
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Preeclampsia, Autoimmunity and The At1 Receptor
… autoantibodies: the angiotensin II type 1 receptor activating autoantibody (AT1-AA). These autoantibodies act as angiotensin II and stimulate the ubiquitous AT1 receptor. To elucidate the role of AT1-AA in the pathophysiology of PE, a model of adoptive transfer was generated wherein AT1-AA …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… homeostasis in the body. Angiotensin II type 1 (AT1) receptor is the key component of RAS that is implicated in hypertension. Oxidative stress is considered one of the main causes of hypertension. Studies including in our own lab showed that oxidative stress increases renal AT1 receptor function …
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Arterial Wall Hypertrophy and PDGF-A Expression in One-Kidney, One-Clip Hypertension and Angiotensin II Infusion Are Mediated By Elevated Arterial Pressure
… hypertension or sham operation. Losartan, an AT1 receptor antagonist, was administered chronically to half of each surgical group beginning one day before the operation and continued until the end of the study. In a second experiment, rats were implanted with osmopumps delivering either ANG II …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway within the kidney and other tissues may antagonize the Ang II-AT1 receptor …
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Vascular receptor changes in ischemic stroke
… systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… of ANG II and BK, their antagonists (AT 2 receptor antagonist PD 123319, AT1 receptor antagonist EXP3174, B2 receptor antagonist HOE 140, B1 receptor antagonist (Leu9 ) Des Arg 10- KD (1 ?M), and nitric oxide synthase inhibitor L-NAME."--Résumé abrégé par UMI
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese animal and contribute to natriuresis. However, the role of AT2 receptors in oxidative stress and inflammation is not well studied. On the other hand, oxidative …
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Alterations in the Brain Renin-Angiotensin System in a Model of Fetal Programming
… angiotensin (Ang) II. In the brain, the Ang II AT1 receptor opposes the beneficial actions of Ang-(1-7) at the Mas receptor for control of baroreflex sensitivity and blood pressure regulation. Our goal was to identify BM induced alterations in the central RAS that are consistent with functional …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of the massive …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… designed to investigate the presence of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from primary tissue of 11 patients who had the disease. My hypothesis is that myofibroblasts will express angiotensin receptors and that these will primarily be of the AT1 receptor subtype. …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… cell caveolae are known to localize the Ang-II (AT1) receptor and regulate renin-angiotensin signaling. Based on these findings, we evaluated the role of caveolae in AAA formation in the murine model. Here, eight week old mice were co-infused with Ang-II and BAPN, a lysyl oxidase inhibitor, to …
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… blockade with the angiotensin (Ang) II type 1 (AT1) receptor antagonist L-158,809 in the F344 rats prevented the age-related increase in serum leptin, insulin, glucose, body weight and increased excretion of Ang peptides and protein that occur independently of blood pressure or plasma RAS …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… alle Effekte der aktiven Metabolite über den AT1-Rezeptor vermittelt und somit durch den selektiven AT1-Rezeptorblocker EXP 3174 aufgehoben. Eine Beteiligung des AT2-Rezeptors auf die renale Druckantwort und Noradrenalinfreisetzung konnte ausgeschlossen werden. Ang I und Ang II vermittelte in …
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Einfluß von Losartan auf das L-Arginin/NO-System im ischämischen akuten Nierenversagen der Ratte
… wurde Losartan gegeben, ein selektiver AT1-Antagonist. Die AT1-Rezeptoren sind die Zielrezeptoren von Angiotensin-II, das als einer der stärksten Vasokonstriktoren im akuten Nierenversagen vermehrt freigesetzt wird. Durch selektive Blockade dieser Rezeptoren durch Losartan soll ebenfalls …
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Charakterisierung und in vitro - Wirkung agonistischer AT1-Rezeptor Autoantikörper bei Präeklampsie-Patienten
… Autoantikörper, die gegen den Angiotensin II AT1-Rezeptor gerichtet sind (AT1-AAK), nachweisen. Diese AT1-AAK gehören zur Antikörpersubklasse IgG3. Die AT1-AAK führen in Kulturen neonataler Rattenkardiomyozyten AT1-Rezeptor spezifisch zu einem positiv chronotropen Effekt. Mittels …