Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"AT1 cells"”.
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Understanding Intercellular Signaling During Lung Injury-Repair
… signaling relationship between alveolar type 1 (AT1) cells and capillary endothelial cells. We also applied our interactome to a hyperoxia model for bronchopulmonary dysplasia, another injury model affecting a majority of lung cell types. In concert with our sequencing approaches to study …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell type-specific ChIP-seq, ATAC-seq, and scRNA-seq, our study shows that AT1 and AT2 cells both express and require Nkx2-1 for their development and maintenance through NKX2-1 mediated …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… signaling. Despite such importance, mesenchymal cells are poorly defined morphologically and molecularly. Their signaling regulation is not well understood, lagging their counterparts in the epithelial, endothelial, and immune lineages. Leveraging single-cell RNA-seq, three-dimensional imaging, …
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Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury
Neutrophils as key effector cells of the innate immune system migrate from the circulation into sites of inflammation and are essential for the containment, killing and clearance of invading pathogens through a variety of highly regulated cell functions. Despite this beneficial role their …