Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"AT1"”.
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Preeclampsia, Autoimmunity and The At1 Receptor
… II type 1 receptor activating autoantibody (AT1-AA). These autoantibodies act as angiotensin II and stimulate the ubiquitous AT1 receptor. To elucidate the role of AT1-AA in the pathophysiology of PE, a model of adoptive transfer was generated wherein AT1-AA isolated from human sera are …
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Charakterisierung des Angiotensin II AT1-Rezeptors in humanen differenzierten Podozyten
… Es wurden hierzu besonders die Eigenschaften des AT1-Rezeptors untersucht. Mittels Messung der [Ca2+]i wurde die Funktionalität des AT1-Rezeptors nachgewiesen. Auch konnte gezeigt werden, dass Angiotensin II direkt auf verschiedene Schlitzmembranproteine humaner differenzierter Podozyten wirkt. …
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Charakterisierung und in vitro - Wirkung agonistischer AT1-Rezeptor Autoantikörper bei Präeklampsie-Patienten
… Autoantikörper, die gegen den Angiotensin II AT1-Rezeptor gerichtet sind (AT1-AAK), nachweisen. Diese AT1-AAK gehören zur Antikörpersubklasse IgG3. Die AT1-AAK führen in Kulturen neonataler Rattenkardiomyozyten AT1-Rezeptor spezifisch zu einem positiv chronotropen Effekt. Mittels …
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Superoxide via Sp3 Transcription Factor Up-Regulates Renal AT1 Receptor Function and Contributes to Hypertension
… homeostasis in the body. Angiotensin II type 1 (AT1) receptor is the key component of RAS that is implicated in hypertension. Oxidative stress is considered one of the main causes of hypertension. Studies including in our own lab showed that oxidative stress increases renal AT1 receptor function …
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Die Entwicklung des myokardialen Hypertrophiebildes im Magnetokardiogramm und die Veränderungen unter dem AT1-Antagonisten Losartan in einem transgenen Rattenmodell
… Depolarisationszeit. Durch die Applikation des AT1-Antagonisten Losartan fanden Veränderungen im magnetokardiographischen Bild der Hypertrophieentwicklung statt. Dadurch näherten sich zum Studienende die Losartangruppe (dTGR/Los) den gesunden Kontrolltieren an. Nur der IHi in QRSGesamt …
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The Effect of 1,25-Dihydroxy Vitamin D3 on AT1 Cell Receptor Expression in Human Iliac Artery Endothelial Cells (HIAEC)
<p>The renin-angiotensin system (RAS) plays an important part in homeostasis through angiotensin IPs role as a vasoconstrictor. Defects in the renin angiotensin system can lead to hypertension, heart attack, and stroke (Weir, 1999). Studies have shown an inverse relationship between Vitamin D3 and …
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Effets centraux d'antagonistes non-peptidiques sélectifs pour les récepteurs AT1 ou AT2 de l'angiotensine II chez le rat hypertendu spontanément
… pour cette fonction est différent des sites AT1 et AT2.
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell type-specific ChIP-seq, ATAC-seq, and scRNA-seq, our study shows that AT1 and AT2 cells both express and require Nkx2-1 for their development and maintenance through NKX2-1 mediated …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… investigate the presence of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from primary tissue of 11 patients who had the disease. My hypothesis is that myofibroblasts will express angiotensin receptors and that these will primarily be of the AT1 receptor subtype. Initially, the …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… (angina pectoris) have increased expression of AT1 and ETB receptors in vascular smooth muscle cells (VSMC) in subcutaneous resistance arteries. 2. The level of the up-regulation of contractile AT1 and ETB receptors depends on the degree of underlying IHD. The phenomenon is also correlated to …
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Arterial Wall Hypertrophy and PDGF-A Expression in One-Kidney, One-Clip Hypertension and Angiotensin II Infusion Are Mediated By Elevated Arterial Pressure
… hypertension or sham operation. Losartan, an AT1 receptor antagonist, was administered chronically to half of each surgical group beginning one day before the operation and continued until the end of the study. In a second experiment, rats were implanted with osmopumps delivering either ANG II …
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… of myofibroblasts and Ang-II receptors (AT1 and AT2) within breast capsule tissue were also investigated using immunohistochemistry. The results show that myofibroblasts were present in all capsules (n=12). Ang-II receptors were present in 50% (n=6) of capsules (paraffin and cryostat …
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The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… functional patterns of NOS isoforms, renin, and AT1 and AT2 receptors in immature preglomerular resistance microvessels utilizing novel microdissection techniques; and (4) determine AII regulation of NOS expression and function in the immature renal vasculature using AT1 and AT2 receptor …
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Einfluß von Losartan auf das L-Arginin/NO-System im ischämischen akuten Nierenversagen der Ratte
… wurde Losartan gegeben, ein selektiver AT1-Antagonist. Die AT1-Rezeptoren sind die Zielrezeptoren von Angiotensin-II, das als einer der stärksten Vasokonstriktoren im akuten Nierenversagen vermehrt freigesetzt wird. Durch selektive Blockade dieser Rezeptoren durch Losartan soll ebenfalls …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… alle Effekte der aktiven Metabolite über den AT1-Rezeptor vermittelt und somit durch den selektiven AT1-Rezeptorblocker EXP 3174 aufgehoben. Eine Beteiligung des AT2-Rezeptors auf die renale Druckantwort und Noradrenalinfreisetzung konnte ausgeschlossen werden. Ang I und Ang II vermittelte in …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… to IL-11 expression and AA development via AT1 receptors and PIEZO1 channels. METHODS: To simulate these BSMKO conditions, aortic VSMCs were pharmacologically treated with AngII and Yoda1. This treatment is expected to enhance calcium influx via AT1 receptors and PIEZO1 channels, resulting …
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Proliferationsverhalten kultivierter Mesangialzellen und glatter Gefäßmuskelzellen nach Stimulation mit Angiotensin II und atherogenen Lipoproteinen : Rezeptorbeteiligung
… gezeigt werden. Die spezifische Hemmung des AT1-Rezeptors mit Losartan bewirkte ebenfalls keine signifikanten Änderungen. Auch die Inkubation der Zellen mit Agenzien, die die AT1-Rezeptordichte erhöhen sollten, erbrachte im Western Blot keine Veränderungen. Im Vergleich unterschiedlich alter …
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Vascular receptor changes in ischemic stroke
… MCA. This contraction is mediated by angiotensin AT1 receptors. In addition the mRNA levels for angiotensin converting enzyme were increased, which may suggest an enhanced production of angiotensin II. 6. A low dose of the AT1 receptor blocker candesartan (0.05 mg/kg and day) in the acute phase of …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese animal and contribute to natriuresis. However, the role of AT2 receptors in oxidative stress and inflammation is not well studied. On the other hand, oxidative …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… Wnt signaling. We know that the alveolar type 1 (AT1) epithelial cell signals via Vascular Endothelial Growth Factor A towards the lung vasculature. Given the large surface area of the AT1 cell, we hypothesized they had additional signaling roles. AT1 cells express canonical Wnt ligands, …
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