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Showing 1 to 1 of 1 for “"ASPIRe-1"”.
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
… For the chemical genetics approach, we designed ASPIRe-1 (Allele-Specific, Proximity-Induced Reactivity-based inhibitor-1), a cell-permeable compound that selectively inhibits katanin with an engineered cysteine mutation. Only in cells expressing mutant katanin, ASPIRe-1 treatment increases the …