Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"ASOS"”.
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Station Exposure and Resulting Bias in Temperature Observations: A Comparison of he Kentucky Mesonet and ASOS Data
… nearby Automated Surface Observation Systems (ASOS) stations in Kentucky. The ASOS stations are located at Louisville International Airport (Standiford Field - KSDF) and at Lexington Airport (Blue Grass Field - KLEX). The null hypothesis states that there is no significant difference in …
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Developing in vitro models to elucidate the mechanisms of toxicity of locked nucleic acid gapmer antisense oligonucleotides.
… to play a vital role in the tolerability of ASOs. This study investigated the safety of antisense oligonucleotides by developing a toolbox of in vitro assays for assessing liver toxicity. HepG2/C3A cells were used as a cellular model to categorise the toxicity of tool ASOs and identify …
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Postoperative outcomes associated with procedural sedation conducted by physician and non-physician anaesthesia providers: findings from the prospective, Observational African Surgical Outcomes Study (ASOS)
Background There is an unmet need for essential surgical services in Africa. Limited anesthesia services are a contributing factor. Non-physician anesthesia providers are utilized to assist with providing anesthesia and procedural sedation in order to make essential surgeries available. There is a …
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Developing the detectability, identifiability, and trackability analysis for the space sustainability rating
… and Tracking of Anthropogenic Space Objects (ASOs). For much of the space age, the onus for improving global SSA has fallen primarily on the ground-based satellite surveillance and tracking community, leading to more technically advanced and powerful sensing systems. With the focus on …
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Quality control and analysis of an updated wind gust data set in the United States
… set for 679 Automated Surface Observing Systems (ASOS) stations across the Continental United States (CONUS) and explores limitations and implications for long return period wind speed estimation. In total, the data set contains more than 17.9 million peak wind gusts, including nearly double the …
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Barriers to clinical research in Africa, a quantitative and qualitative survey of 27 African countries
… survey of African Surgical Outcomes Study (ASOS) investigators, including 29 quantitative Likert scale questions and eight qualitative questions with subsequent thematic analysis. Protocol compliant and non-compliant countries were compared according to the WHO statistics for research and …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… recycling, we used Antisense oligonucleotides (ASOs) to knockdown VISTA expression on myeloid cells. ASOs are synthetically generated single stranded oligonucleotides that alter messenger RNA to either diminish, recover, or adapt protein expression. We hypothesize that reducing VISTA expression …
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ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… vehicles for antisense oligonucleotides (ASOs). RBCEVs inhibited both pseudotyped and authentic SARS-CoV-2 infections in a dose-dependent manner by blocking viral entry. ASOs targeting conserved viral genes (helicase, 3CLPro, PLpro, RdRp, and TRS), delivered via RBCEVs, significantly …
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Postoperative outcomes associated with surgical care for women in Africa: an international risk-adjusted analysis
… analysis of the African Surgical Outcomes Study (ASOS) focusing on severe postoperative complications (defined as death and severe complications) in females following non-obstetric, non-gynaecological surgical procedures. ASOS was a seven-day, African multi-centre prospective observational cohort …
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Investigating and Reprogramming RNA Folding with Molecular Probes
… by short antisense oligonucleotides (ASOs) to fold into six different 3D wireframe polyhedra. How each type of structural feature in the polyhedra affects the stability of local base pairs is revealed using dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq). Second, the …
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Comparing mortality calculators for emergency laparotomy in Cape Town
… (P-POSSUM), and African Surgical Outcomes Study (ASOS) to 215 patients who underwent non-trauma EL in a tertiary level hospital in South Africa. Results Mortality on post-operative day 30 in this cohort was 24.2%. Colorectal resections were most performed and had the highest mortality rate …
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Antisense Reduction of the Protein Tau Attenuates Neuronal Hyperexcitability and Permits Clearance of Intraneuronal Tau Accumulations in vivo
… protein tau using Antisense Oligonucleotides (ASOs) to reduce total expression of tau <italic> in vivo </italic> and assess if such a reduction could be therapeutically beneficial. To first test the feasibility of reducing tau in the adult animal, we identified ASOs that reduce endogenous mouse …
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Interrogating Dux4 Mrna 3′ End Processing
… we designed antisense oligonucleotides (ASOs) to impair the production of polyadenylated Dux4. Prior to antagonizing Dux4 CPA, we demonstrate, in proof of principle experiments that ASOs directed toward required CPA regulatory elements can impair gene expression, and may redirect …
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Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological barriers
… delivery of antisense oligonucleotides (ASOs) and chemotherapeutics. First, we address the issue that the optimal peptide sequence for the delivery of a macromolecular cargo is often context-dependent and specific to that cargo. With one class of ASO, we develop a paradigm that combines …
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Exploring the relationship between the growing number of satellites and space debris in low earth orbit, and people's perception of space debris environmental impacts
… a comprehensive analysis of all monitored ASOs in Earth's orbit by presenting and exploring the current state of space debris and the relationship to the active satellites in Earth's orbit. The findings of this study will contribute to ongoing efforts to address the challenges of space …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… functions using antisense oligonucleotides (ASOs) dampens DDR in a sequence-specific matter, impeding repair. Consistent with the persistence of DDR activation at ALT telomeres, we observed increased transcription of telomeric dilncRNA in ALT cells compared to non-ALT. Since DDR pathways are …
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Impacts of cold pool strength on tornado production in quasi-linear convective systems
… from Automated Surface Observing System (ASOS) sites. Low-level and deep-layer vertical wind shear and storm-relative helicity (SRH) were obtained from hourly 13 km resolution Rapid Refresh model (RAP) analyses at the nearest hour prior to the arrival of the QLCS cold pool. Every ASOS site …
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Improving Cardiac Delivery of Antisense Oligonucleotides with Peptidomimetic Targeting Agents
… the delivery of antisense oligonucleotides (ASOs) to inhibit the expression of an overexpressed miRNA in CVD, miRNA-21. One of the challenges in delivering ASOs and other gene therapies is achieving delivery to the desired tissue before the therapeutic is trafficked to the liver or kidneys. …
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HIV in the heartland: negotiating disclosure, stigma, & the HIV community
… when individuals seek formal support via ASOs (AIDS service organizations), and/or informal support through family members and friends. The purpose of this research is to investigate these negotiations over the course of HIV infection, how these processes inform decisions to disclose, how …
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Insights from biomolecular condensates into disease and drug development
… work to show that antisense oligonucleotides (ASOs), nucleic acid-based therapeutics targeting RNA, partition into and modulate certain condensates, and that specific chemical modifications can alter this partitioning behavior. Ultimately, by considering the implications of a condensate model …
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