Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ASK1"”.
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The Role of ASK1 in Allergen-mediated Mast Cell Signaling and Activation-dependent Inflammatory Responses
… Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) that is involved in various cellular responses, including oxidative stress, high calcium concentrations and receptor-mediated inflammation. ASK1 has been known to be a key player in various …
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
… Oxidized Trx is inactive and unable to bind to ASK1 thereby activating ASK1 and causing cell death via p38/JNK pathways thereby contributing to the pathogenesis of myocardial ISC-REP injury. In this study we have shown that inhibition of ASK1 protects the heart during REP via the modulation of …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… with 14-3-3ε and Apoptosis Signaling Kinase 1 (ASK1). In contrast, CDC25C did not require 14-3-3 binding or cytoplasmic localization to suppress apoptosis, but rather resulted in inhibitory phosphorylation of pro-apoptotic BAD and elevation of the anti-apoptotic survivin. These data suggest that …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… p38 MAPK signaling pathway downstream of MAP3K5/ASK1, indicative of a feed-forward signaling loop wherein self-perpetuated GR phosphorylation enables cancer cell autonomy. A 24-gene pS134-GR-dependent signature induced by TGFβ1 predicts shortened overall survival in breast cancer patients. …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… with a cellular response involving the ASK1/p38 axis, which is implicated in the regulation of catalase expression and the activation of apoptotic signals. In conclusion, the results of our study provide evidence that a rational combination of prooxidant agents may be effective in …