Global ETD Search
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Showing 1 to 3 of 3 for “"ASIC1a"”.
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… peripheral ASICs, I also studied mechanisms of ASIC1a neuropeptide modulation. Modulation of ASIC can potentiate or inhibit its activity and therefore may affect physiological and pathological roles of ASIC. Yet, the mechanism of peptide modulation of ASIC is unknown. I have discovered a …
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Identification of Novel Acid-Sensing Ion Channel 3 Modulators using in silico Modelling and Screening
… based on published 3D structures of chicken ASIC1a solved at various states. These models were then used for blind docking with some known small molecule modulators of ASIC3 that notably included the NSAID diclofenac. The resultant poses of these ligands were then subjected to further …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
<p>Cell death is not only an essential phenomenon in normal development and homeostasis, but also crucial in various pathologies. It is now clear that many types of cell death can be regulated by pharmacological or genetic interventions. These were largely achieved by identifying the molecular …