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Showing 1 to 3 of 3 for “"ASGR"”.
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Functional Significance of Glycoprotein Clearance by the Asialoglycoprotein Receptor and the Mannose/GalNAc-4-SO4 Receptor
… has shown that the asialoglycoprotein receptor: ASGR) is capable of clearing glycoproteins bearing terminal Siaalpha2,6GalNAc as well as ones bearing terminal Gal/ GalNAc and that the Mannose/GalNAc-4-SO4 receptor: MR) is capable of clearing glycoproteins bearing terminal GalNAc-4-SO4. I am …
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RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
… that binds to the asialoglycoprotein receptor (ASGR), allowing targeted delivery to hepatocytes. I hypothesized that ASGR might still be sufficiently expressed in FLC tumors to deliver siRNAs to cells in vivo. I demonstrated that indeed ASGR is still expressed across different stages of the FLC …
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
… di effetti extra-epatici di GalNAc-siACLY, topi Asgr -/- sono stati sottoposti allo stesso regime terapeutico e dietetico dei gruppi precedenti. Questi animali mancano, infatti, del recettore epatico ASGR1, recettore responsabile dell’uptake selettivo da parte del fegato. Anche in questo gruppo …