Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"ASCT2"”.
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
… through downregulating glutamine transporter ASCT2, which is in an EGFR-kinase activity inhibition independent manner. Applications of these mechanism studies lead to findings of novel therapeutic targets to improve cetuximab responses and/or overcome cetuximab resistance. We proved that …
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The development of novel metabolic therapies for the treatment of glioblastoma
… glutamine through overexpressing the transporter ASCT2. Key rate-limiting enzymes involved in the utilisation of glutamine for de novo nucleotide synthesis (PPAT, CAD) were upregulated in the large majority of tumour biopsies, while those involved in glutaminolysis (GLS1, GLS2) were …