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Showing 1 to 2 of 2 for “"AS1949490"”.
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Synthesis, Design, and Biological Evaluation of Inhibitors and Activators of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) and Synthetic Studies of Apicularen A and Maoecrystal V
… synthesis of thiophene based SHIP2 inhibitors AS1949490 and AS1938909 and some analogs of these molecules. SHIP2 inhibitors have potential therapeutic application to breast cancer treatment since overexpression of SHIP2 in breast cancer supports cell proliferation while its suspension retards …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
<p>The lymphatic system is essential for the transport of excess fluid, protein, and foreign materials from interstitial tissues to lymph nodes; for immune surveillance, and to maintain fluid homeostasis. Dysregulated lymphatics can be attributed to pathological conditions including tumor …