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Showing 1 to 20 of 28 for “"ARPE-19"”.

  1. Der Einfluss von Trägermaterialien und Proteinbeschichtungen auf die Zellkultur des retinalen Pigmentepithels

    Böser, SebastianChristian-Albrechts-Universität zu Kiel

    … RPE auswirken.Es wurden die humane RPE Zelllinie ARPE-19 sowie primäre porcine RPE-Zellen verwendet. Eine Beschichtung von Zellkulturplatten mit Laminin führt zu einem signifikant höheren Wachstum von ARPE-19 verglichen mit den Kollagenen. Das RPE zeigte auf den verschiedenen Beschichtungen keine …

    cau-kiel Repository record

  2. Regulation der Metalloproteinasen Stromelysin und Collagenase durch Interferon in retinalen Pigmentepithelzellen

    Meisenzahl, ChristinaUniversität Würzburg

    … ob in der humanen Pigmentepithelzellinie ARPE-19 die Metalloproteinasen Stromelysin und Collagenase produziert werden und ob die Genexpression dieser Metalloproteinasen durch eine Behandlung der Zellen mit humanen Interferonen stimuliert werden kann. Der Nachweis sollte auf der mRNA-Ebene …

    wurz-thes Repository record

  3. Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies

    Koirala, Diwa2020

    … and proteome changes due to oxLDL treatment in ARPE-19 cells.</p> <p>We studied the role of scavenger receptors CD36 and CD5L/AIM in ARPE-19 cells when induced with oxLDL. We compared three different multidimensional proteome fractionation platforms: polymeric reversed-phase liquid …

    tenn-hsc Repository record

  4. Wirkung von Algenextrakten aus Fucus distichus subspecies evanescens auf das retinale Pigmentepithel

    Rohwer, Kevin MichaelChristian-Albrechts-Universität zu Kiel

    … Phagozytose und Wundheilung in RPE- bzw. ARPE-19-Zellen. Die Zellviabilität primärer RPE blieb unbeeinflusst, während ARPE-19-Zellen nach 1 und 7 Tagen eine signifikante Reduktion zeigten. Eine relevante Protektion gegenüber TBH-induziertem oxidativem Stress zeigte sich nicht. Die …

    cau-kiel Repository record

  5. Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress

    Gerdes, BryanUniversity of Missouri -- Kansas City2018

    … in the retinal pigment epithelial cell line ARPE-19 and primary isolated optic nerve head astrocytes as models for cells supporting the viability and function of retinal neurons. The use of siRNA in both ARPE-19 and ONHA cell lines demonstrated how the loss of endogenous Nampt affected each …

    umkc Repository record

  6. Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders

    이, 기황2015

    … fibrogenesis in the human RPE cell line (ARPE)-19 was tested. Methods: The effect of pirfenidone on the TGF-β1-induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin. Fibronectin and collagen production was measured with enzyme-linked …

    ajou Repository record

  7. Investigating how mitophagy is regulated by the metabolic context

    Montava Garriga, LambertUniversity of Dundee2020

    … mitophagy with the mito-QC reporter and the ARPE-19 cell line as a new model system, from which I found initial hints for a new regulatory role of AMPK in mitophagy. I secondly developed a proteomic approach using APEX2 biotin proximity labelling to detect changes in mitophagy signalling from …

    dundee Repository record

  8. Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration

    Satish, Sangeeta2018

    … In-vitro experiments were performed on the ARPE-19 cell line. Cells were treated with 10µM of ZLN005 for 24 hours. Oxidative stress was induced by exposure to H2O2 and NaIO3 under serum-free conditions. Lactate dehydrogenase (LDH) levels were used to quantify cell death. Quantitative PCR …

    bu Repository record

  9. Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking

    Egbejimi, AnuoluwapoThe University of Texas Medical Branch at Galveston2022

    … is validated using Chloroquine treatment of ARPE-19 cells and knockdown of Atg5. This unique assay gives specific information regarding the trafficking of POS to the lysosome within the RPE. The assay is useful for uncovering novel factors involved in the trafficking stage of POS …

    utmb Repository record

  10. In vitro evaluation of Ultraviolet Radiation (UVR) exposure of the Retinal Pigmented Epithelium (RPE) and its relevance to Age-Related Macular Degeneration (AMD)

    Anderson, GrahamThe University of Edinburgh2021

    … we exposed the immortalised RPE cell line, aRPE-19, to 10nm bands of UVR between 290 and 405nm. To assess physical cell dynamics during exposure, cells were cultured upon specialist electrode culture plates (ECIS®, Applied Biophysics) which allow for electrostatic interrogation of key cell …

    edinburgh Repository record

  11. Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line

    Jwala, JwalaUniversity of Missouri-Kansas City2011

    … (Y-79) and retinal pigment epithelial (ARPE-19) cells. Higher expression of FR-α, SMVT and B (0, +) at mRNA level was observed in cancerous Y- 79 cells compared to normal ARPE-19 cells.

    umkc Repository record

  12. Comparative efficacy of fractionated Cape cobra (Naja nivea) venom on breast and cervical cancer cells

    Palekar, SidrahStellenbosch : Stellenbosch University2026

    … fibroblast (FG0) and retinal pigment epithelial (ARPE-19) cells. Short-term cytotoxicity was assessed by MTT assay and IC50 values calculated. Based on these results, long-term assays were conducted, including clonogenic assays to assess colony-forming ability and scratch assays to assess cell …

    stellenbosch Repository record

  13. Investigating the effect of a small molecule, Inhibitor of Nuclear Import (INI-43) as a pan-cancer treatment

    Rahman, ShabitaDepartment of Integrative Biomedical Sciences (IBMS)2024

    … compared to the non-cancer epithelial cell line (ARPE-19) with EC50 values of ~ 5 - 15 µM for the cancer cell lines and ~ 25 µM for the non-cancer cell line, ARPE-19, which is at least two- RHMSHA007 fold higher than the EC50 values of majority of the cancer cell lines. INI-43 treatment also …

    cape-town Repository record

  14. Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]

    GIUFFRIDA, ERIKAUniversità degli studi di Catania2025

    … (oBRB) in un modello in vitro della RD (cellule ARPE-19 sottoposte a elevate concentrazioni di glucosio). Inoltre, sono stati utilizzati dei ligandi selettivi di questi recettori come strumento farmacologico al fine di studiare il ruolo di α1DR e α2CR. L'attività mitocondriale è stata valutata …

    catania Repository record

  15. Nuove prospettive terapeutiche per la protezione della retina

    CONTI, FEDERICAUniversità degli studi di Catania2022

    … infiammazione/neurodegenerazione retinica, quali ARPE-19 (cellule epiteliali retiniche umane) trattate con lipopolisaccaride (LPS) e topi sottoposti a danno retinico indotto da I/R. In questi modelli, la caffeina ha ridotto l’infiammazione ed ha determinato un aumento dei livelli di mRNA del BDNF. …

    catania Repository record

  16. A study of the beneficial role of thiol antioxidant supplementation in various forms of glutathione deficiency

    Abraham, Linu SaraMissouri University of Science and Technology2016

    … damage in retinal pigment epithelial cells, ARPE-19. The second model of glutathione deficiency used was fibroblast cell lines derived from patients with hereditary glutathione synthetase enzyme deficiency. Thirteen different fibroblasts were investigated for their basal levels of …

    must-thes Repository record

  17. Therapeutic effects of N-acetylcysteine amide in the treatment of eye disorders

    Carey, Joshua W.Missouri University of Science and Technology2016

    … integrity of adult retinal pigmented epithelial ARPE-19 cells in the presence of methamphetamine. The second was an <em>in vivo</em> model which examined the cataract generating potential upon the depletion of glutathione levels within the lens. Treatment with N-acetylcystiene amide was applied …

    must-thes Repository record

  18. INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE

    AURILIA, MIRIAMUniversità degli Studi di Milano2025

    … RNAs, which silence specific genes) in a human ARPE-19 CLN3 knockout (CLN3KO) cell model. The survey identified 84 candidate genes whose depletion reduced Gb3 levels. We focused on the top candidate hit, Estrogen-related receptor alpha (ESRRA/ESRRA), a nuclear receptor involved in mitochondrial …

    milano Repository record

  19. Redox mechanisms in retinal cells

    Wherry, Lydia ElspethUniversity of East Anglia2012

    … heme oxygenase-1 (HO-1) in the human ARPE-19 retinal epithelial cell line In contrast, SFN significantly increased HO-1 and NAD(P)H:quinine oxidoreductase 1 (NQO1), but not ferritin or Thioredoxin (Trx1) expression in MIO-M1 cells, which are Nrf2 target genes. SFN also increased Nrf2 …

    east-anglia Repository record

  20. Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma

    Chavarkar, Gauri RajendraCreighton University2026

    … conditions. Preliminary cytotoxicity studies in ARPE-19 cells indicated acceptable cytocompatibility of GYY4137 loaded (≥ 87.62%) and blank microparticles (≥ 76.6%) within the tested concentration range. Overall, this study demonstrates the potential of PCL-based microparticles as a sustained …

    creighton Repository record

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