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Showing 1 to 2 of 2 for “"ARNT2"”.
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Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2
… or repress target gene expression. ARNT and ARNT2 are homologues that are common dimerisation partners for many other bHLH/PAS transcription factors. Previous attempts to generate knockout mice of ARNT and ARNT2 transcription factors have resulted in embryonic or perinatal lethality due to …
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Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
… in mammalian and aquatic species. While ARNT and ARNT2 exhibit >90% amino acid identity in the bHLH and PAS domains, gene knock-out of either ARNT or ARNT2 results in embryonic/perinatal lethality characterized by distinct phenotypes. This suggests that neither protein can compensate fully for the …