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Showing 1 to 2 of 2 for “"ARNT isoforms"”.
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ARNT isoforms differentially regulate cancer cell growth through a p53-dependent mechanism.
Aryl hydrocarbon receptor nuclear translocator (ARNT) is an important player in xenobiotic and hypoxic responses. In addition to this, my mentor has shown that ARNT is an integral cofactor of NF-kB signaling. However, these initial observations of ARNT-mediated NF-kB modulation were based on …
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Investigation of ARNT isoform-specific regulation of AHR signaling
… aryl hydrocarbon receptor nuclear translocator (ARNT) is alternatively spliced into two distinct isoforms, isoform 1 and 3. Although ARNT is found to be critical in immunity, xenobiotic, and hypoxic response, ARNT isoform-specific function has yet to be investigated. We previously demonstrated …